{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T05:56:25Z","timestamp":1722318985467},"reference-count":105,"publisher":"Informa Healthcare","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Drug Safety"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1517\/14740338.2.4.347","type":"journal-article","created":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T11:41:44Z","timestamp":1115206904000},"page":"347-365","source":"Crossref","is-referenced-by-count":4,"title":["Safety and efficacy of disease-modifying antirheumatic agents in rheumatoid arthritis and juvenile rheumatoid arthritis"],"prefix":"10.1517","volume":"2","author":[{"given":"Roy","family":"Fleischmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3197","published-online":{"date-parts":[[2005,3,3]]},"reference":[{"key":"CIT0001","unstructured":"KOOPMAN WJ: Arthritis and Allied Conditions (14th edn). Lippincott Williams & Wilkins, Philadelphia, PA (2001)."},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/oxfordjournals.epirev.a036058","volume":"12","author":"HOCHBERG MC","year":"1990","journal-title":"Epidemiol Rev."},{"key":"CIT0003","first-page":"427","volume":"16","author":"LAWRENCE RC","year":"1989","journal-title":"J. Rheumatol"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1007\/BF02239187"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300421"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.12.1403"},{"key":"CIT0009","unstructured":"BORIGINI MJ, PAULUS HE: Rheumatoid arthritis. In: Treatment of Rheumatic Disease Companion to Kelley's Textbook of Rheumatology (2nd edn). WII Saunders Co. Philadelphia, PA (2001)."},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1002\/art.10148"},{"key":"CIT0011","first-page":"21","volume":"80","author":"SIGLER JW","year":"1974","journal-title":"DUNCAN Het al.: Gold salts in the treatment of rheumatoid arthritis. A double-blind study. Ann. Intern. Med."},{"key":"CIT0012","first-page":"1","volume":"34","author":"LUUKKAINEN R Chrysotherapy in rheumatoid arthritis with particular emphasis on radiograph changes and on the optimal time of initiation of therapy","year":"1980","journal-title":"J. Rheumatol. Suppl."},{"key":"CIT0013","unstructured":"GORDON DA, KLINKHOFF AV: Gold and penicillamine. In: Ruddy: Kelley's Textbook of Rheumatology (6th edn). WII Saunders Co. St Louis, MO (2001)."},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140605"},{"key":"CIT0015","first-page":"26","volume":"35","author":"VAN DER HEIDE DM, VAN LEEWEN MA,","year":"1991","journal-title":"VAN RIEL PL et al.: Biannual radiographic assessments of hands and feet in the three-year prospective follow-up of patients with early rheumatoid arthritis. Arthritis Rheum."},{"key":"CIT0016","first-page":"1","volume":"56","author":"SVARTZ N","year":"1948","journal-title":"Rheumatism"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1136\/ard.8.3.226"},{"key":"CIT0018","first-page":"476","volume":"73","author":"KUZELL WC","year":"1950","journal-title":"Calif: Med"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1007\/BF01968673"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6212.442"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6399.1099"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6399.1102"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.3.194"},{"issue":"12","key":"CIT0024","first-page":"1427","volume":"29","author":"PINALS RS","year":"1986","journal-title":"A double-blind, placebo-controlled trial. Arthritis Rheum."},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310602"},{"issue":"10","key":"CIT0026","first-page":"16724677","volume":"19","author":"THE AUSTRALIAN MULTICENTRE CLINICAL TRIAL GROUP","year":"1992","journal-title":"J. Rheumatol."},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361104"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331001"},{"issue":"61","key":"CIT0030","first-page":"760","volume":"11","author":"THOMPSON RN","year":"1984","journal-title":"J. Rheumatol."},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503283121303"},{"issue":"3","key":"CIT0035","first-page":"358","volume":"107","author":"TUG WELL P","year":"1987","journal-title":"Indications, contraindications, efficacy, and safety. Ann. Intern. Med"},{"issue":"5","key":"CIT0037","first-page":"577","volume":"31","author":"KREMER JM","year":"1988","journal-title":"Update after a mean of fifty-three months. Arthritis Rheum."},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1007\/BF02204463"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/28.2.147"},{"key":"CIT0040","first-page":"471","volume":"62","author":"BANNWARTH B","year":"1995","journal-title":"Rev. Rheum."},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(90)90020-G"},{"issue":"4","key":"CIT0043","first-page":"633","volume":"24","author":"GALINDO-RODRIGUEZ G","year":"1997","journal-title":"J. RheumatoL"},{"key":"CIT0045","first-page":"4","volume":"1","author":"ALARCON GS","year":"1999","journal-title":"Rheum. Arthritis Idx Rev."},{"issue":"21","key":"CIT0046","first-page":"2542","volume":"159","author":"STRAND V","year":"1999","journal-title":"Leflunomide Rheumatoid Arthritis Investigators Group. Arch. Intern. Med"},{"issue":"6","key":"CIT0048","first-page":"797","volume":"107","author":"NORDSTROM DM","year":"1987","journal-title":"A controlled prospective roentgenographic study. Ann. Intern. Med."},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.3109\/03009748909099932"},{"issue":"3","key":"CIT0050","first-page":"342","volume":"9","author":"DROSOS AA","year":"1990","journal-title":"Rheumatol"},{"issue":"12","key":"CIT0051","first-page":"9994004","volume":"114","author":"JEURISSEN ME","year":"1991","journal-title":"A randomized, double blind study. Ann. Intern. Med."},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341006"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361006"},{"key":"CIT0057","first-page":"1885","volume":"19","author":"PINCUS T","year":"1992","journal-title":"J. Rheum."},{"issue":"10","key":"CIT0058","first-page":"1117","volume":"35","author":"FELSON DT","year":"1992","journal-title":"A meta-analysis of published clinical trials. Arthritis Rheum."},{"key":"CIT0059","first-page":"619","volume":"9","author":"WOLFE F","year":"1995","journal-title":"Clin. Rheum."},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380602"},{"issue":"11","key":"CIT0061","first-page":"1595","volume":"38","author":"MLADENOVIC V","year":"1995","journal-title":"Results of a randomized, placebo-controlled, Phase II study. Arthritis Rheum."},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09403-3"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.10.913"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1322::AID-ANR4>3.0.CO;2-P"},{"key":"CIT0069","first-page":"726","volume":"137","author":"KREMER JM","year":"2002","journal-title":"A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med."},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01300-7"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.207"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1038\/322547a0"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.22.8749"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441207"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05992.x"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117130"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331204"},{"key":"CIT0080","first-page":"225","volume":"6","author":"BUTLER DM","year":"1995","journal-title":"Eur. Cytokine Nett\u00b0."},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199812)41:12<2196::AID-ART15>3.0.CO;2-2"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1002\/art.10578"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5<1001::AID-ANR7>3.0.CO;2-P"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1002\/art.10141"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(93)90106-L"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1995.1003"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361206"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90628-9"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO;2-W"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05246-0"},{"key":"CIT0098","first-page":"1594","volume":"343","author":"LIPSKY PE","year":"2000","journal-title":"CLAIR EW et al.: Inffiximab and methotrexate in the treatment of rheumatoid arthritis. N EngL J. Med."},{"key":"CIT0105","first-page":"1849","volume":"23","author":"MORELAND LW","year":"1996","journal-title":"J. Rheum."},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707173370301"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00004"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901283400401"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432201"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1002\/art.10308"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003163421103"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1002\/art.10710"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1002\/art.10697"},{"key":"CIT0135","first-page":"153","volume":"7","author":"RICHTER JA","year":"1980","journal-title":"J. Rheumatol"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296907"},{"key":"CIT0137","first-page":"74","volume":"14","author":"GISPEN JG","year":"1987","journal-title":"J. Rheumatol"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/XXXIV.suppl_4.49"},{"key":"CIT0145","doi-asserted-by":"publisher","DOI":"10.1002\/art.10524"},{"key":"CIT0150","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.8.738"},{"key":"CIT0151","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7152.180"},{"key":"CIT0152","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(96)00210-9"},{"key":"CIT0153","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2383::AID-ANR2>3.0.CO;2-D"},{"key":"CIT0154","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200225030-00004"},{"key":"CIT0165","unstructured":"YOCUM DE: Safety of infliximab. Presented at the Centocor Symposium, American College of Rheumatology, New Orleans (2002)."},{"key":"CIT0166","doi-asserted-by":"publisher","DOI":"10.1002\/art.10679"},{"key":"CIT0168","doi-asserted-by":"publisher","DOI":"10.1002\/art.10758"},{"key":"CIT0169","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011110"},{"key":"CIT0171","unstructured":"KEYSTONE E: Update on Biologics. Presented at EULAR, Stockholm, Sweden (2002)."},{"key":"CIT0176","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2862::AID-ART474>3.0.CO;2-W"},{"issue":"12","key":"CIT0178","first-page":"517","volume":"72","author":"WOOTEN MD","year":"2000","journal-title":"DeL Med. J."},{"issue":"8","key":"CIT0179","first-page":"2041","volume":"27","author":"GALARIA NA","year":"2000","journal-title":"J. Rheumatol"},{"key":"CIT0180","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2606::AID-ANR31>3.0.CO;2-X"},{"key":"CIT0182","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200004)43:4<944::AID-ANR29>3.0.CO;2-Y"},{"key":"CIT0183","doi-asserted-by":"publisher","DOI":"10.1002\/art.10885"},{"issue":"565","key":"CIT0185","first-page":"27","volume":"29","author":"FLEISCHMANN RM","year":"2002","journal-title":"Rheum."},{"key":"CIT0188","volume":"4","author":"http:\/\/www.fda.govllohrms\/dockets\/ados\/ briefing\/","year":"2003","journal-title":"htm FDA Briefing Information"},{"key":"CIT0191","volume":"16","author":"http:\/\/www.fda.gov\/ohrms\/dockets\/ac\/","year":"2001","journal-title":"pclf Kineret (analcinra) FDA Briefing Information"}],"container-title":["Expert Opinion on Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14740338.2.4.347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T15:04:35Z","timestamp":1497625475000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14740338.2.4.347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":105,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,3,3]]},"published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1517\/14740338.2.4.347"],"URL":"https:\/\/doi.org\/10.1517\/14740338.2.4.347","relation":{},"ISSN":["1474-0338","1744-764X"],"issn-type":[{"value":"1474-0338","type":"print"},{"value":"1744-764X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}