{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:51:11Z","timestamp":1773143471890,"version":"3.50.1"},"reference-count":88,"publisher":"Informa Healthcare","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Drug Safety"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1517\/14740338.4.6.1069","type":"journal-article","created":{"date-parts":[[2005,10,28]],"date-time":"2005-10-28T14:38:45Z","timestamp":1130510325000},"page":"1069-1082","source":"Crossref","is-referenced-by-count":10,"title":["Safety and efficacy of growth hormone replacement therapy in adults"],"prefix":"10.1517","volume":"4","author":[{"given":"Andy","family":"Toogood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3197","published-online":{"date-parts":[[2005,10,28]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0021-9258(19)52796-X","volume":"159","author":"LI CH","year":"1945","journal-title":"Biolog. Chem."},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3235.1293"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-18-8-901"},{"key":"CIT0004","first-page":"82","volume":"266","author":"RABEN MS","year":"1962","journal-title":"2 Clinical use of human growth hormone. N Engl. I Med."},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-2-288"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198912283212605"},{"key":"CIT0008","first-page":"1221","volume":"1","author":"JORGENSEN JOL, PEDERSEN SA, THUESEN L et al.","year":"1989","journal-title":"Lancet"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1210\/jcem.80.12.8530603","volume":"80","author":"BURMAN P","year":"1995","journal-title":"J. Clin. Endocrine]. Metab."},{"key":"CIT0013","first-page":"613","volume":"42","author":"HOLMES SJ","year":"1995","journal-title":"Chu. Endocrine]."},{"key":"CIT0015","first-page":"333","volume":"51","author":"WALLYMAHMED ME","year":"1999","journal-title":"Chu. Endocrine]."},{"key":"CIT0016","first-page":"63","volume":"2","author":"HOLMES SJ","year":"1995","journal-title":"Endocrine]. Metab."},{"key":"CIT0017","first-page":"82","volume":"82","author":"ATTANASIO AF","year":"1997","journal-title":"I Chu. Endocrine]. Metab."},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.1.5408"},{"key":"CIT0019","first-page":"173","volume":"1","author":"BESHYAH SA","year":"1994","journal-title":"Endocrine]. Metab."},{"key":"CIT0020","first-page":"179","volume":"42","author":"BESHYAH SA","year":"1995","journal-title":"Chu. Endocrine]"},{"key":"CIT0021","first-page":"229","volume":"60","author":"LONN L KVIST","year":"1993","journal-title":"Basic Life Science"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.9.2.153"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-2-254"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00682.x"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(94)90245-3"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(93)90145-E"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/acta.0.1290195","volume":"129","author":"ROSEN T","year":"1993","journal-title":"Acta Endocrinol"},{"key":"CIT0029","first-page":"481","volume":"141","author":"SANMARTI A","year":"1999","journal-title":"Collaborative ODA (Observational GH Deficiency in Adults) Group. Eur.j Endocrinol."},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01832.x"},{"key":"CIT0032","first-page":"453","volume":"84","author":"PFEIFER M","year":"1999","journal-title":"I Clin. Endocrinol. Metab."},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91812-O"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04006-X"},{"key":"CIT0037","first-page":"1169","volume":"81","author":"BATES AS VAN","year":"1996","journal-title":"I Clin. Endocrinol. Metab."},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x","volume":"46","author":"BULOW B","year":"1997","journal-title":"Endocrinol"},{"key":"CIT0041","first-page":"669","volume":"78","author":"HOLMES SJ","year":"1994","journal-title":"Clin. Endocrinol Metab."},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.7.8593"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030126"},{"key":"CIT0044","first-page":"1462","volume":"82","author":"TOOGOOD AA","year":"1997","journal-title":"I Clin. Endocrinol. Metab."},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1370240"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.2.398"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb02583.x"},{"key":"CIT0048","first-page":"379","volume":"83","author":"GROWTH HORMONE RESEARCH SOCIETY","year":"1998","journal-title":"I Clin. Endocrinol Metab."},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1046\/j.1365-2265.1996.00855.x","volume":"45","author":"RAHIM A","year":"1996","journal-title":"Endocrinol"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.671492.x"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.19.2.0329"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.3.6487-1"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01829"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6454.1257"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.123"},{"key":"CIT0058","first-page":"111","volume":"133","author":"SESMILO G","year":"2000","journal-title":"A randomized, controlled clinical trial. Ann. Intern. Med."},{"key":"CIT0059","first-page":"1874","volume":"86","author":"COLAO A","year":"2001","journal-title":"I Clin. Endocrinol Metab."},{"key":"CIT0060","first-page":"1668","volume":"83","author":"CHRISTOPHER M","year":"1998","journal-title":"I Clin. Endordnol. Metab."},{"key":"CIT0061","first-page":"975","volume":"79","author":"O'NEAL DN","year":"1994","journal-title":"JClin. Endocrinol Metab."},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8482"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1054\/ghir.2000.0134"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.8.5916"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.11.6171-1"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-4-916"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1991.tb00930.x"},{"key":"CIT0068","first-page":"41","volume":"131","author":"JUUL A","year":"1994","journal-title":"Fur. I Endordnol."},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1992.tb02901.x"},{"key":"CIT0070","first-page":"409","volume":"39","author":"VANDEWEGHE M","year":"1993","journal-title":"Endordnol."},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.69.817.846"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1992.tb02287.x"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb03936.x"},{"key":"CIT0075","first-page":"1671","volume":"77","author":"AMATO G","year":"1993","journal-title":"I Clia Endocrinol Metab."},{"key":"CIT0076","first-page":"180","volume":"133","author":"DEGERBLAD M","year":"1995","journal-title":"Fur. I Endocrinol"},{"key":"CIT0077","first-page":"42","volume":"132","author":"BALDUCCI R","year":"1995","journal-title":"Fur. I Endordnol."},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900392"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02690.x"},{"key":"CIT0080","first-page":"1344","volume":"76","author":"O'HALLORAN DJ","year":"1993","journal-title":"I Clin. Endocrinol Metab."},{"key":"CIT0081","first-page":"1818","volume":"82","author":"BRAVENBOER N","year":"1997","journal-title":"DE BOER H et al.: The effect of growth hormone on histomorphometric indices of bone structure and bone turnover in GH deficient men. I Clin. Endocrinol Metab."},{"key":"CIT0082","first-page":"2865","volume":"81","author":"JOHANNSSON G","year":"1996","journal-title":"I Clin. Endocrinol Metab."},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02591.x"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02021.x"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.3310\/hta6180"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01908.x"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.2801076.x"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.11.7997"},{"key":"CIT0089","first-page":"1684","volume":"89","author":"ROSILIO M","year":"2004","journal-title":"WE EDWARDS DJ et al.: Long-term improvement of quality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H). Clin. Endocrinol Metab."},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01909.x"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00838.x"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00722.x"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.4.0438"},{"key":"CIT0096","first-page":"348","volume":"56","author":"ROSEN CJ","year":"1994","journal-title":"Biochem."},{"key":"CIT0097","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1046\/j.1365-2265.1997.1660984.x","volume":"46","author":"CHIPMAN JJ","year":"1997","journal-title":"Endocrinol"},{"key":"CIT0098","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2265.2000.01108.x","volume":"53","author":"FLORAKIS D","year":"2000","journal-title":"Endocrinol"},{"key":"CIT0099","first-page":"2730","volume":"83","author":"ORME SM","year":"1998","journal-title":"United Kingdom Acromegaly Study Group. j Clin. Endocrinol Metab."},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-2-245"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.9.6775"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.563"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10384-1"},{"key":"CIT0106","first-page":"4444","volume":"85","author":"SWERDLOW AJ","year":"2000","journal-title":"EndocrinolMetab"}],"container-title":["Expert Opinion on Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14740338.4.6.1069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T23:05:12Z","timestamp":1626649512000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14740338.4.6.1069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,28]]},"references-count":88,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,10,28]]},"published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1517\/14740338.4.6.1069"],"URL":"https:\/\/doi.org\/10.1517\/14740338.4.6.1069","relation":{},"ISSN":["1474-0338","1744-764X"],"issn-type":[{"value":"1474-0338","type":"print"},{"value":"1744-764X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,28]]}}}