{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:27:51Z","timestamp":1791329271717,"version":"4.3.1"},"reference-count":149,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1517\/17425255.2.3.351","type":"journal-article","created":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T06:55:47Z","timestamp":1148972147000},"page":"351-366","source":"Crossref","is-referenced-by-count":209,"title":["Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition"],"prefix":"10.1517","volume":"2","author":[{"given":"Gabriele","family":"Jedlitschky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyo K","family":"Kroemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2006,5,30]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1101\/gr.GR-1649R"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.6.080604.162122"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1007\/s004250100661"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1080\/09687860500042013"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.16.1295"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.102301.093055"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206953"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520170111"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.1.137"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.15091"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5252.1126"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250635"},{"key":"CIT0013","first-page":"4124","volume":"56","author":"TANIGUCHI","year":"1996","journal-title":"Cancer Res."},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-195409000-00001"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840070204"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050408"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016278008658"},{"key":"CIT0018","doi-asserted-by":"crossref","unstructured":"KOENIG M, NIES AT, CUI Y, KEPPLERD: MRP2, the apical export pump for anionic conjugates. In:\n                      ABC Transporters from Bacteria to Man\n                      .\n                      IB Holland, SPC Cole, K Kuchler, CF Higgins (Eds), Academic press, London, UK (2003):423-443.","DOI":"10.1016\/B978-012352551-2\/50021-4"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1042\/bj3270305"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300220"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28648"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1681\/ASN.V1061159","volume":"10","author":"SCHAUB","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.12.1788"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0022-3565(24)39291-2","volume":"293","author":"MOTTINO","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2003.07.003"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(01)00480-1"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.07.051"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1728"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.12301.x"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.049858"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2003.22603.x"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"R1495","DOI":"10.1152\/ajpregu.2000.279.4.R1495","volume":"279","author":"ST","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.003335"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.05.010"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.1.97"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(99)00162-5"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005149200"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303504200"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1007\/s01869-005-1869-8"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1124\/mol.59.5.1077","volume":"59","author":"ITO","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"38108","DOI":"10.1074\/jbc.M105160200","volume":"276","author":"ITO","year":"2001","journal-title":"J. Biol. Chem."},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"G1034","DOI":"10.1152\/ajpgi.2001.281.4.G1034","volume":"281","author":"ITO","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204267200"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.02832.x"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.38.23623"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.004481"},{"key":"CIT0047","first-page":"G16","volume":"272","author":"ITO","year":"1997","journal-title":"Am. J. Physiol."},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1124\/mol.57.4.760","volume":"57","author":"BAKOS","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0026-895X(24)23190-4","volume":"55","author":"CUI","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1124\/mol.60.5.934","volume":"60","author":"CUI","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109081200"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.081224"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1124\/mol.66.2.330"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.014605"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(05)00029-7"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007171"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.16.9675"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102453200"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.17.7690"},{"key":"CIT0060","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0026-895X(24)12532-1","volume":"56","author":"VAN","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1262"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199811)20:11<931::AID-BIES8>3.0.CO;2-J"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008251200"},{"key":"CIT0064","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0022-3565(24)39265-1","volume":"293","author":"LOE","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0065","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1124\/mol.59.5.1171","volume":"59","author":"LESLIE","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00416.2003"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01015-8"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.002477"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.006262"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.085589"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00007.x"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000143473.64430.AC"},{"key":"CIT0073","doi-asserted-by":"crossref","first-page":"G522","DOI":"10.1152\/ajpgi.2000.278.4.G522","volume":"278","author":"CANTZ","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1021\/mp0340136"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200211220-00009"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1728"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.6.798"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.001420"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00699-4"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.063073"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.057729"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.34"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.059105"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-2-16"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-005-0042-3"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01615-5"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022238506509"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-4062"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200505000-00002"},{"key":"CIT0090","first-page":"3537","volume":"57","author":"KOOL","year":"1997","journal-title":"Cancer Res."},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12313.x"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20899"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1080\/10408440590905948"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1080\/15287390500195570"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(03)00043-2"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20003"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.5414\/CPP41610"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000048205.02478.b5"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00271.2003"},{"key":"CIT0100","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1124\/mol.59.5.974","volume":"59","author":"DIETRICH","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.02110s5689"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1021\/tx0342060"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh265"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.2.578"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.07.003"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8340"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01106.x"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300617"},{"key":"CIT0109","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/hep.510260427","volume":"26","author":"KAUFFMANN","year":"1997","journal-title":"Hepatology"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)01295-8"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70138-1"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109326200"},{"key":"CIT0113","doi-asserted-by":"crossref","first-page":"10836","DOI":"10.1016\/S0021-9258(18)82061-0","volume":"268","author":"FERNANDEZ-CHECA","year":"1993","journal-title":"J. Biol. Chem."},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00899-0"},{"key":"CIT0115","doi-asserted-by":"crossref","first-page":"G438","DOI":"10.1152\/ajpgi.2000.278.3.G438","volume":"278","author":"OGAWA","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00097-6"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/66.1.16"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050571"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.10.004"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64794-3"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70103-3"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.20895"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9388"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90649-5"},{"key":"CIT0125","first-page":"G1041","volume":"272","author":"GATMAITAN","year":"1997","journal-title":"Am. J. Physiol."},{"key":"CIT0126","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1242\/jcs.111.8.1137","volume":"111","author":"ROELOFSEN","year":"1998","journal-title":"J. Cell Sci."},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290319"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33327"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1038\/ng905"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00410-0"},{"key":"CIT0131","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/hep.510230519","volume":"23","author":"KARTENBECK","year":"1996","journal-title":"Hepatology"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105047200"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70459-2"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.2.203"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200103000-00008"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.035014"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(00)00355-2"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-4062"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.04.011"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330241"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1498"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012292230480"},{"key":"CIT0143","first-page":"1798","volume":"7","author":"YOUNG","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"CIT0144","first-page":"2931","volume":"24","author":"FANEYTE","year":"2004","journal-title":"Anti-Cancer Res."},{"key":"CIT0145","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10246"},{"key":"CIT0146","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1344"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.1159\/000074531"},{"key":"CIT0148","first-page":"349","volume":"5","author":"LISCOVITCH","year":"2002","journal-title":"Drugs"},{"key":"CIT0149","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.10427"}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/17425255.2.3.351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T22:29:59Z","timestamp":1736375399000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/17425255.2.3.351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,30]]},"references-count":149,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,5,30]]},"published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1517\/17425255.2.3.351"],"URL":"https:\/\/doi.org\/10.1517\/17425255.2.3.351","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,30]]}}}