{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:54:18Z","timestamp":1785459258344,"version":"3.56.0"},"reference-count":98,"publisher":"Informa UK Limited","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1517\/17425255.2012.695347","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T19:17:30Z","timestamp":1350328650000},"page":"1157-1172","source":"Crossref","is-referenced-by-count":26,"title":["Role of reactive metabolites in the circulation in extrahepatic toxicity"],"prefix":"10.1517","volume":"8","author":[{"given":"Roy M","family":"Irving","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan A","family":"Elfarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2012,6,11]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1177\/106002809302700206","volume":"27","author":"Einarson TR","year":"1993","journal-title":"Ann Pharmacother"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.15.1200"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.17.2215"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.2174\/1389200054021799"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.5.1327"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(88)90009-9"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0022-3565(25)20618-8","volume":"232","author":"Uetrecht JP","year":"1985","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:5<900::AID-CNCR2820200552>3.0.CO;2-Y"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.06.002"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1043"},{"key":"CIT0011","first-page":"S287","volume":"27","author":"Sood C","year":"1996","journal-title":"Br J Cancer Suppl"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1021\/bi990125k"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(88)90592-9"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1515\/znc-1975-7-808","volume":"30","author":"Esterbauer H","year":"1975","journal-title":"Z Naturforsch C"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90137-8"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm127"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1021\/tx100172x"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1021\/ja00381a037"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(80)90033-2"},{"key":"CIT0020","first-page":"1","volume-title":"Target organ toxicity","author":"Cohen G","year":"1986"},{"key":"CIT0021","first-page":"519","volume-title":"Introduction to biochemical toxicology","author":"Tarloff JB","year":"1994"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1152\/ajplegacy.1969.217.4.1057","volume":"217","author":"Tune BM","year":"1969","journal-title":"Am J Physiol"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1152\/ajplegacy.1973.225.5.1114","volume":"225","author":"Tune BM","year":"1973","journal-title":"Am J Physiol"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1159\/000401060"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(79)90078-4"},{"key":"CIT0026","first-page":"357","volume":"47","author":"Williams PD","year":"1985","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"CIT0027","first-page":"257","volume-title":"Toxicology of the kidney","author":"Tune BM","year":"1993"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1177\/019262339802600102"},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0022-3565(25)22379-5","volume":"270","author":"Shimada T","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.38.1.389"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90159-T"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0026-895X(25)09155-2","volume":"50","author":"Haehner BD","year":"1996","journal-title":"Mol Pharmacol"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/53.2.458"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90576-7"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90251-Q"},{"key":"CIT0036","first-page":"F338","volume":"259","author":"Lash LH","year":"1990","journal-title":"Am J Physiol"},{"key":"CIT0037","first-page":"449","volume-title":"Renal toxicology","author":"Safirstein RL","year":"1997","edition":"1"},{"key":"CIT0038","first-page":"159","volume-title":"Renal Toxicology","author":"Fogo A","year":"1997","edition":"1"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050271"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/41.2.157"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/49.5.299"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1021\/tx950171v"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1021\/bi00534a041"},{"key":"CIT0044","first-page":"1145","volume":"43","author":"Miller RE","year":"1983","journal-title":"Cancer Res"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(86)90527-7"},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"13076","DOI":"10.1016\/S0021-9258(18)69273-7","volume":"261","author":"Lash LH","year":"1986","journal-title":"J Biol Chem"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj107"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)61031-5"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1080\/009841099158204"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050283"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1016\/S0021-9258(17)38472-7","volume":"261","author":"Lash LH","year":"1986","journal-title":"J Biol Chem"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0026-895X(25)10356-8","volume":"31","author":"Elfarra AA","year":"1987","journal-title":"Mol Pharmacol"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(90)90319-P"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1021\/tx900219x"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.120444"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050367"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-003-0459-6"},{"key":"CIT0058","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0022-3565(25)38701-X","volume":"269","author":"Lash LH","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1042\/bj0900588"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1042\/bj1070217"},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0090-9556(25)07837-7","volume":"10","author":"Waring RH","year":"1982","journal-title":"Drug Metab Dispos"},{"key":"CIT0062","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1016\/S0021-9258(19)39303-2","volume":"265","author":"Sausen PJ","year":"1990","journal-title":"J Biol Chem"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.152058"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.9965"},{"key":"CIT0065","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S1016-8478(23)13372-3","volume":"7","author":"Chung WG","year":"1997","journal-title":"Mol Cells"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.12.020"},{"key":"CIT0067","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0026-895X(24)13493-1","volume":"51","author":"Ripp SL","year":"1997","journal-title":"Mol Pharmacol"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.042911"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200202000-00018"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(97)00055-0"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1995.1100"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1021\/tx950075u"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1154"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)02107-8"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.6.755"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1021\/tx700263w"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1021\/tx00024a010"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1021\/tx800060z"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1021\/tx9001429"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1021\/tx00046a012"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1021\/tx025671k"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046185"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.05.016"},{"key":"CIT0084","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0026-895X(25)13037-X","volume":"32","author":"Lash LH","year":"1987","journal-title":"Mol Pharmacol"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-3565(24)29523-9","volume":"297","author":"Lash LH","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1021\/tx200263n"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1021\/bi060551n"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1021\/tx700433m"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0094"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(71)90242-5"},{"key":"CIT0091","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0022-3565(25)11245-7","volume":"260","author":"Sausen PJ","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0092","first-page":"3632","volume":"44","author":"Jacobs C","year":"1984","journal-title":"Cancer Res"},{"key":"CIT0093","first-page":"557","volume":"73","author":"Wilson JR","year":"1977","journal-title":"Ohio State Med J"},{"key":"CIT0094","first-page":"36","volume":"96","author":"Yunis AA","year":"1980","journal-title":"J Lab Clin Med"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3464-3469.2003"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6313.421-d"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2011.07.002"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.02.016"}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/17425255.2012.695347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T05:15:03Z","timestamp":1744434903000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/17425255.2012.695347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,11]]},"references-count":98,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2012,8,17]]},"published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1517\/17425255.2012.695347"],"URL":"https:\/\/doi.org\/10.1517\/17425255.2012.695347","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,11]]}}}