{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:47:56Z","timestamp":1790664476001,"version":"4.1.0"},"reference-count":105,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1517\/17425255.2013.759558","type":"journal-article","created":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T03:53:34Z","timestamp":1358567614000},"page":"403-421","source":"Crossref","is-referenced-by-count":16,"title":["Metabolic and toxicological considerations for the latest drugs used to treat irritable bowel syndrome"],"prefix":"10.1517","volume":"9","author":[{"given":"Shilan","family":"Mozaffari","sequence":"first","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekoufeh","family":"Nikfar","sequence":"additional","affiliation":[{"name":"Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences","place":["Iran"]},{"name":"Food & Drug Laboratory Research Center, Food and Drug Organization, Ministry of Health and Medical Education","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2013,1,19]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210794079254"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i7.589"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.7.1129"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X10387203"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2313"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i5.547"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00669-3"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i36.4504"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152812798889394"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9335-z"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2010.13507"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03368.x"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07234.x"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9104-6"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.355"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1004409"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9839-8"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.651458"},{"key":"e_1_3_2_21_1","first-page":"51","article-title":"Pharmacokinetic study of rifaximin after oral administration in healthy volunteers","volume":"14","author":"Descombe JJ","year":"1994","unstructured":"Descombe JJ, Dubourg D, Picard M, Palazzini E. Pharmacokinetic study of rifaximin after oral administration in healthy volunteers. Int J Clin Pharmacol Res 1994;14:51-6","journal-title":"Int J Clin Pharmacol Res"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01108-07"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-8-200610170-00004"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.11.50"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2008.05.002"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03730.x"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.031"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01771.x"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802240255"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000150632"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800670"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000070202"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.152330"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.005"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0466-x"},{"key":"e_1_3_2_36_1","first-page":"760","article-title":"Acute, subacute and chronic oral toxicity studies of the new serotonin (5-HT) 3-receptor antagonist ramosetron in beagle dogs","volume":"45","author":"Tabata H","year":"1995","unstructured":"Tabata H, Matsuzawa T, Hanada T, Acute, subacute and chronic oral toxicity studies of the new serotonin (5-HT) 3-receptor antagonist ramosetron in beagle dogs. Arzneimittelforschung 1995;45:760-6","journal-title":"Arzneimittelforschung"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.1931"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05011.x"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03884.x"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01398.x"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.05.024"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2009.00737.x"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00958.x"},{"key":"e_1_3_2_44_1","first-page":"417","article-title":"Toxicity of non-steroidal anti-inflammatory drugs: a review of melatonin and diclofenac sodium association","volume":"27","author":"Ayg\u00fcn D","year":"2012","unstructured":"Ayg\u00fcn D, Kaplan S, Odaci E, Toxicity of non-steroidal anti-inflammatory drugs: a review of melatonin and diclofenac sodium association. Histol Histopathol 2012;27:417-36","journal-title":"Histol Histopathol"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/50.2.271"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2007.10.015"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.7.B311"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38731.532766.F6"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.0243.x"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i38.4251"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2011.00028"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.110858"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02685.x"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.127514"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.302.3.1013"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.259"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536200-000000000-00000"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645110-00002"},{"key":"e_1_3_2_59_1","first-page":"594","article-title":"Severe myoclonus from pregabalin (Lyrica) due to chronic renal insufficiency","volume":"46","author":"Murphy NG","year":"2008","unstructured":"Murphy NG, Mosher L. Severe myoclonus from pregabalin (Lyrica) due to chronic renal insufficiency. Clin Toxicol 2008;46:594","journal-title":"Clin Toxicol"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.04.014"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000179854.16846.67"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70226-X"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01922.x"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01183.x"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-11.2011"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00011.2009"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41081.x"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.043596"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645120-00003"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP40198"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP43444"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S4537"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1702-2"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00264.2005"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01668.x"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03881.x"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03320.x"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04983.x"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03629.x"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01524.x"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01776.x"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01385.x"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2011.572875"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2011.5.3.253"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.050"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010863"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.067"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(11)60561-1"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03870.x"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00076.2012"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04730.x"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006059902700501"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i2.237"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04656.x"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04958.x"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2012.707179"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.29396"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04328.x"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01732.x"},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02673.x"},{"key":"e_1_3_2_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.062034"},{"key":"e_1_3_2_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31802df84c"},{"key":"e_1_3_2_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0463-z"},{"key":"e_1_3_2_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.07.011"},{"key":"e_1_3_2_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00458.x"},{"key":"e_1_3_2_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(08)62544-5"},{"key":"e_1_3_2_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04088.x"}],"container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/17425255.2013.759558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:36:50Z","timestamp":1770381410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1517\/17425255.2013.759558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,19]]},"references-count":105,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1517\/17425255.2013.759558"],"URL":"https:\/\/doi.org\/10.1517\/17425255.2013.759558","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,19]]}}}