{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:11:34Z","timestamp":1791259894763,"version":"4.1.0"},"reference-count":107,"publisher":"Informa UK Limited","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1517\/17425255.4.8.1119","type":"journal-article","created":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T06:15:21Z","timestamp":1217916921000},"page":"1119-1129","source":"Crossref","is-referenced-by-count":162,"title":["Ambroxol in the 21st century: pharmacological and clinical update"],"prefix":"10.1517","volume":"4","author":[{"given":"Mario","family":"Malerba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Ragnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2008,8,4]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14b35.x"},{"key":"CIT0002","first-page":"1176","volume":"52","author":"Rogers","year":"2007","journal-title":"Respir Care"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1159\/000195274"},{"key":"CIT0005","first-page":"84","volume":"55","year":"1989","journal-title":"Respiration"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7297.1271"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2003.08.004"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7297.1259"},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/030006059502300409","volume":"23","author":"Caramina","year":"1995","journal-title":"J Int Med Res"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441781"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1987.15.3.227"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1007\/BF02113258"},{"key":"CIT0013","first-page":"424","volume":"46","author":"Siergiejko","year":"1991","journal-title":"Pol Tyg Lek"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90506-6"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1007\/BF02714144"},{"key":"CIT0016","first-page":"480","volume":"5","author":"Szmeja","year":"1997","journal-title":"Otolaryngol Pol"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.41.1175"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1159\/000195270"},{"key":"CIT0019","first-page":"71","volume":"67","author":"Allegra","year":"1985","journal-title":"Eur J Respir Dis"},{"key":"CIT0020","first-page":"63","volume":"67","author":"Robertson","year":"1985","journal-title":"Eur J Respir Dis"},{"key":"CIT0021","first-page":"129","volume":"2","author":"Pfeifer","year":"1997","journal-title":"Eur J Med Res"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.3.433"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.10.058"},{"key":"CIT0024","first-page":"889","volume":"28","author":"Pueschmann","year":"1978","journal-title":"Drug Res"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.88.57"},{"key":"CIT0026","first-page":"274","volume":"71","author":"Kyle","year":"1987","journal-title":"Eur J Respir Dis"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1159\/000193595"},{"key":"CIT0028","first-page":"694","volume":"80","author":"Cunningham","year":"1983","journal-title":"Br J Pharmacol"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(76)90066-9"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-4452"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2004.133"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1159\/000194035"},{"key":"CIT0033","first-page":"47","volume":"13","author":"Elemer","year":"1983","journal-title":"Curr Probl Clin Biochem"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1159\/000390647"},{"key":"CIT0035","first-page":"287","volume":"71","author":"Ziegler","year":"1987","journal-title":"Eur J Respir Dis"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1159\/000194430"},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0002-9378(78)90435-0","volume":"130","author":"Petten van","year":"1978","journal-title":"Am J Obstet Gynecol"},{"key":"CIT0039","first-page":"135","volume":"16","author":"Dauberschmidt","year":"1980","journal-title":"Eur Physiopath Resp"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1007\/s004330050049"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(96)00431-6"},{"key":"CIT0042","first-page":"132","volume":"49","author":"Lapenna","year":"1994","journal-title":"Pharmacologica"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90130-9"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2002.910309.x"},{"key":"CIT0045","first-page":"149","volume":"165","author":"Winsel","year":"1985","journal-title":"Z Erkrank Atm Organe"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)00028-V"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705497"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2003.920407.x"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00739-1"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050374"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050244"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000162"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01609-0"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2001-y"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00448-9"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.2.629"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.02.004"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00253302"},{"key":"CIT0059","first-page":"263","volume":"12","author":"Wada","year":"1981","journal-title":"Iyakuhin Kenkyu"},{"key":"CIT0060","first-page":"281","volume":"21","author":"Tsunenari","year":"1981","journal-title":"Pharmacometrics"},{"key":"CIT0061","first-page":"273","volume":"12","author":"Wada","year":"1981","journal-title":"Iyakuhin Kenkyu"},{"key":"CIT0062","first-page":"337","volume":"12","author":"Wada","year":"1981","journal-title":"Iyakuhin Kenkyu"},{"key":"CIT0063","first-page":"303","volume":"12","author":"Makita","year":"1981","journal-title":"Iyakuhin Kenkyu"},{"key":"CIT0064","first-page":"271","volume":"21","author":"Iida","year":"1981","journal-title":"Pharmacometrics"},{"key":"CIT0065","first-page":"358","volume":"12","author":"Matsuzawa","year":"1981","journal-title":"Iyakuhin Kenkyu"},{"key":"CIT0066","first-page":"371","volume":"12","author":"Matsuzawa","year":"1981","journal-title":"Iyakuhin Kenkyu"},{"key":"CIT0068","first-page":"179","volume":"13","author":"Mezetti","year":"1990","journal-title":"J Emerg Surg Intensive Care"},{"key":"CIT0070","first-page":"904","volume":"28","author":"Jauch","year":"1978","journal-title":"Arzneimittelforschung Drug Res"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1080\/004982500237839"},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1183\/09031936.93.02080702","volume":"2","author":"Pride","year":"1989","journal-title":"Eur Respir J"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08081333"},{"key":"CIT0074","first-page":"248","volume":"69","author":"Ericsson","year":"1986","journal-title":"Eur J Respir Dis"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1159\/000195273"},{"key":"CIT0076","first-page":"700","volume":"50","author":"Matthys","year":"2000","journal-title":"Arzneimittelforschung"},{"key":"CIT0077","first-page":"734","volume":"43","author":"Fraschini","year":"1988","journal-title":"Curr Ther Res"},{"key":"CIT0078","first-page":"5","volume":"12","author":"Perez-Neria","year":"1992","journal-title":"Compend Invest Clin Lat Am"},{"key":"CIT0079","first-page":"359","volume":"35","author":"Weiss","year":"1981","journal-title":"Prax Pneumol"},{"key":"CIT0080","first-page":"A120","volume":"69","author":"Olivieri","year":"1986","journal-title":"Eur J Respir Dis"},{"key":"CIT0081","first-page":"715","volume":"42","author":"Cegla","year":"1988","journal-title":"Prax Klin Pneumol"},{"key":"CIT0082","first-page":"956","volume":"55","author":"Grassi","year":"1985","journal-title":"Lotta Contro Tuberc Malat Polm Soc"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1378\/chest.92.4.618"},{"key":"CIT0084","first-page":"51","author":"Serra","year":"1981","journal-title":"Ann Med Sondalo"},{"key":"CIT0085","first-page":"84","volume":"55","author":"Alcozer","year":"1989","journal-title":"Respiration"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.5.1278"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1001\/jama.272.19.1497"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00269802"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906243402503"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7245.1297"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050647"},{"key":"CIT0092","first-page":"83","volume":"11","author":"Huizar","year":"1984","journal-title":"Invest Med Int"},{"key":"CIT0093","first-page":"369","volume":"6","author":"Principi","year":"1986","journal-title":"Int J Clin Pharmacol Res"},{"key":"CIT0094","first-page":"91","volume":"41","author":"Baldini","year":"1989","journal-title":"Minerva Pediatr"},{"key":"CIT0095","first-page":"23","volume":"4","author":"Careddu","year":"1984","journal-title":"Asthma Bronch Emphys"},{"key":"CIT0096","first-page":"351","volume":"106","author":"Berni","year":"1983","journal-title":"Clin Ter (Roma)"},{"key":"CIT0097","first-page":"127","volume":"36","author":"Romano","year":"1984","journal-title":"Minerva Pediatr"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1159\/000195275"},{"key":"CIT0099","first-page":"599","volume":"50","author":"Golusinski","year":"1996","journal-title":"Otolaryngol Pol"},{"key":"CIT0100","first-page":"7940","volume":"31","author":"Weinmann","year":"1981","journal-title":"Therapiewoche (Karlsruhe)"},{"key":"CIT0101","first-page":"256","volume":"52","author":"Fischer","year":"2002","journal-title":"Arzneimittelforschung"},{"key":"CIT0102","first-page":"194","volume":"52","author":"Schutz","year":"2002","journal-title":"Arzneimittelforschung"},{"key":"CIT0103","first-page":"1","author":"Weingaertner","year":"2004","journal-title":"Bonn Univ"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.5414\/CPP44409"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-456SO"},{"key":"CIT0106","first-page":"828","volume":"38","author":"Dorow","year":"1988","journal-title":"Arzneimittelforschung"},{"key":"CIT0107","first-page":"163","volume":"70","author":"Ericsson","year":"1987","journal-title":"Eur J Respir Dis"},{"key":"CIT0108","first-page":"304","volume":"64","author":"Pavia","year":"1983","journal-title":"Eur J Respir Dis"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(74)90004-7"},{"key":"CIT0110","first-page":"75","author":"Thomson","year":"1974","journal-title":"Scand J Respir Dis"},{"key":"CIT0111","first-page":"824","author":"Camner","year":"1981","journal-title":"Chest"}],"container-title":["Expert Opinion on Drug Metabolism & Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/17425255.4.8.1119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T12:46:58Z","timestamp":1684500418000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/17425255.4.8.1119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":107,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2008,8,4]]},"published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1517\/17425255.4.8.1119"],"URL":"https:\/\/doi.org\/10.1517\/17425255.4.8.1119","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}