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Results: The DSC curves indicated the elimination of the melting endotherm of methyldopa in the binary mixtures. A new peak at 1719 cm-1 was observed in the FTIR spectra that can be attributed to the loss of type one amine functionality. The m\/z of the proposed compound was observed in the mass spectra. Conclusion: The potential incompatibility of Methyldopa with reducing carbohydrates was established using physicochemical methods.<\/jats:p>","DOI":"10.15171\/apb.2018.074","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T04:32:03Z","timestamp":1547785923000},"page":"657-666","update-policy":"https:\/\/doi.org\/10.15171\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients"],"prefix":"10.34172","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-1561","authenticated-orcid":true,"given":"Mohammad Reaz","family":"Siahi","sequence":"first","affiliation":[{"name":"Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran."},{"name":"Department of Pharmaceutical and Food Control, Tabriz University of Medical Sciences, Faculty of Pharmacy, Tabriz, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8581-5692","authenticated-orcid":true,"given":"Soma","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Tabriz University of Medical Sciences, Faculty of Pharmacy, Tabriz, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-5136","authenticated-orcid":true,"given":"Farnaz","family":"Monajjemzadeh","sequence":"additional","affiliation":[{"name":"Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran."},{"name":"Department of Pharmaceutical and Food Control, Tabriz University of Medical Sciences, Faculty of Pharmacy, Tabriz, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1461-5347(99)00158-3","article-title":"Excipients as stabilizers","volume":"2","author":"Crowley PJ","year":"1999","journal-title":"Pharm Sci Technolo Today"},{"key":"R2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S1461-5347(00)00301-1","article-title":"Drug\u2013excipient interactions and their affect on absorption","volume":"3","author":"Jackson K","year":"2000","journal-title":"Pharm Sci Technolo Today"},{"key":"R3","unstructured":"Martindale W, Sweetman SC. 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