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Serotonin being a neurotransmitter synthesized in the raphe nuclei of the brain could serve as an alternative biomarker. Here, the limitation is that it\u2019s quickly metabolized by the mitochondrial enzyme MAO to 5-hydroxy indole acetic acid (5HIAA). This subsequent metabolite can be used for the analysis of serotonin levels in brain by analysing its concentration in the cerebrospinal fluid (CSF). Many theories suggest that the variations in serotonin level could lead to the development of many neurological and psychiatric disorders like Alzheimer\u2019s disease (AD), schizophrenia, depression and so on. A decreased level is noticed in these patients but this could either be due to decreased production or increased reuptake of serotonin from the neuronal synapses. For instance, we know that a patient with depression shows a significant reduction in the levels of 5HIAA, due to the location of the raphe nuclei within regions of memory and cognition. Similarly, it does shows variation in AD and mild cognitive disorder. Evolving of 5HIAA as a biomarker, could be more delicate and enhanced strategy for monitoring these disorders.<\/jats:p>","DOI":"10.15171\/apb.2019.044","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T01:57:25Z","timestamp":1567216645000},"page":"374-381","update-policy":"https:\/\/doi.org\/10.15171\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["5-HIAA as a Potential Biological Marker for Neurological and Psychiatric Disorders"],"prefix":"10.34172","volume":"9","author":[{"given":"Hridya","family":"Jayamohananan","sequence":"first","affiliation":[{"name":"Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneesha Kalappurackal","family":"Manoj Kumar","sequence":"additional","affiliation":[{"name":"Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-8249","authenticated-orcid":true,"given":"Aneesh","family":"T P","sequence":"additional","affiliation":[{"name":"Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2019,8,1]]},"reference":[{"key":"R1","unstructured":"Personalized Medicine Coalition. 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