{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:05:31Z","timestamp":1790834731985,"version":"4.1.0"},"reference-count":24,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["apb.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Adv Pharm Bull"],"abstract":"<jats:p>Purpose: Combination of benzoyl peroxide (BPO) with topical antibiotics can lead to higherefficacy and less bacterial resistance, but it in turn increases adverse effects such as skinirritability and dryness. In this study, the efficacy of combination therapy of niosomal BPO 1%and clindamycin (CL) 1% is compared with niosomal CL in acne vulgaris.Methods: This is a double-blind clinical trial study on 100 patients with acne vulgaris inAfzalipour hospital in Kerman. Patients were randomly divided into 2 groups (case and control).The case group received niosomal combination of BPO 1% and CL 1%.The control groupreceived niosomal CL1%. The efficacy of treatment protocols was evaluated in 2nd, 4th, 8thand 12th weeks of treatment by counting lesions (severity and grading acne lesions) and qualityof life (QoL). Furthermore, side effect were evaluated at each treatment visits.Results: The reduction in mean percentage of acne lesions in case group (treated with BPO 1%and CL1%) (64.21%) was higher than control group (treated with niosomal CL 1%) (59.04%),but the statistical difference was not significant. Sum of excellent and good results were foundin 80% and 76.1% of case and control groups, respectively (P = 0.377). Also adding BPO to thetreatment formulation in case group did not increase adverse effects, as statistical differencebetween 2 groups was not significant.Conclusion: Combination of niosomal BPO 1% and CL 1% in treatment of acne vulgaris showedhigher efficacy with no increase in adverse effects in comparison with niosomal CL 1%, but thestatistical difference was not significant.&lt;br \/&gt;<\/jats:p>","DOI":"10.15171\/apb.2019.066","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T11:59:32Z","timestamp":1574510372000},"page":"578-583","update-policy":"https:\/\/doi.org\/10.15171\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Niosomal Benzoyl Peroxide and Clindamycin Lotion Versus NiosomalClindamycin Lotion in Treatment of Acne Vulgaris: A RandomizedClinical Trial"],"prefix":"10.34172","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-5811","authenticated-orcid":true,"given":"Saman","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1848-5961","authenticated-orcid":true,"given":"Abbas","family":"Pardakhty","sequence":"additional","affiliation":[{"name":"Pharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-7092","authenticated-orcid":true,"given":"Maryam","family":"Khalili","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3501-8409","authenticated-orcid":true,"given":"Reza","family":"Fathi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9845-3531","authenticated-orcid":true,"given":"Maryam","family":"Rezaeizadeh","sequence":"additional","affiliation":[{"name":"Pharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Farajzadeh","sequence":"additional","affiliation":[{"name":"Leishmaniasis Research Center, Afzalipour Hospital, Kerman University of Medical Sciences, 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