{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:33:47Z","timestamp":1790127227120,"version":"4.0.1"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["japid.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Adv Periodontol Implant Dent"],"abstract":"<jats:p>Background. The present study aimed to determine the association between periodontal disease and the Th17\/Treg balance by examining the genetic expression of IL-17 and TGF-\u03b2, which influence incidence and suppression of inflammation. Methods. In this case-control study, samples were collected in a randomized and task-oriented order. Thirty-seven patients referred to professional periodontology clinics in Mashhad and the Periodontology Department of the Mashhad Dentistry Faculty for periodontal (case) or crown-length (control) surgery was enrolled. IL-17 and TGF-\u03b2 gene expression indices were measured in tissue samples by real-time polymerase chain reaction. Results. The IL-17 gene expression index was higher in the case group (2.68\u00b10.91) than in the control group (1.68\u00b10.41), but this difference was not significant. The TGF-\u03b2 gene expression index was significantly higher in the case group (54.42\u00b17.88) than in the control group (24.12\u00b13.38). Conclusion. L-17 and TGF-\u03b2 expression is increased in chronic periodontitis patients, but TGF-\u03b2 plays a more important role in periodontal inflammation in patients with chronic periodontitis. Further studies of the roles of Th17 and Treg cells are warranted.<\/jats:p>","DOI":"10.15171\/japid.2018.002","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:56:42Z","timestamp":1569373002000},"page":"8-12","update-policy":"https:\/\/doi.org\/10.15171\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative evaluation of IL-17 and TGF-\u03b2 expression in tissues of patients with chronic periodontitis and healthy individuals using real-time PCR"],"prefix":"10.34172","volume":"10","author":[{"given":"Kazem","family":"Fatemi","sequence":"first","affiliation":[{"name":"Dental Research Center, Mashhad University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Abdolrahim","family":"Rezaee","sequence":"additional","affiliation":[{"name":"Immunology Research Center, Inflammation and Inflammatory Diseases Division, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Moeintaghavi","sequence":"additional","affiliation":[{"name":"Maxillofacial Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Shiezadeh","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golnaz","family":"Dadpour","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Rasoul","family":"Asadinezhad","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Nasrabadi","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2018,10,10]]},"container-title":["Journal of Advanced Periodontology &amp; Implant Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-83","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-83","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T16:09:22Z","timestamp":1581696562000},"score":1,"resource":{"primary":{"URL":"https:\/\/japid.tbzmed.ac.ir\/Article\/japid-83"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,10]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.15171\/japid.2018.002","relation":{},"ISSN":["2645-5390"],"issn-type":[{"value":"2645-5390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,10]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"}]}}