{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:15:51Z","timestamp":1778660151127,"version":"3.51.4"},"reference-count":22,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["jcvtr.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Thorac Res"],"abstract":"<jats:p>Introduction: Hypertension is common in patients with severe aortic stenosis undertaking transcatheter aortic valve replacement (TAVR).  Renin\u2013angiotensin system (RAS) blockade therapy with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) has recently been associated with improved outcomes after surgical aortic valve replacement and TAVR, but it is unknown if these findings apply to a more rural patient population. Methods: A retrospective cohort study of 169 patients with at least 1 year of post-TAVR follow-up at a single predominantly rural US center was performed to determine if RAS blockade after TAVR affects short- and long-term outcomes. Seventy-one patients were on an ACEI or ARB at the time of TAVR and at 1 year post-TAVR follow-up. Fisher\u2019s exact test was used for categorical data and t-test\/ANOVA was used to determine the statistical significance of continuous variables. Results: In a well-matched cohort, RAS blockade therapy post-TAVR was associated with significantly improved overall survival at 2 years (95% vs. 79%, P = 0.042).  RAS blockade was also associated with a trend towards decreased heart failure exacerbations in the first year after TAVR, which was statistically significant in the 30 days to 6 months timeframe after TAVR (8% vs. 21%, P = 0.032). Conclusion: In a rural patient population, RAS blockade after TAVR is associated with improved overall survival and a trend towards decreased heart failure exacerbations.  This study builds upon previous studies and suggests that TAVR should be considered a compelling indication for these agents.<\/jats:p>","DOI":"10.15171\/jcvtr.2019.30","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T04:13:45Z","timestamp":1568348025000},"page":"176-181","update-policy":"https:\/\/doi.org\/10.15171\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Renin\u2013angiotensin system blockade after transcatheter aortic valve replacement (TAVR) improves intermediate survival"],"prefix":"10.34172","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-9673","authenticated-orcid":true,"given":"Brent","family":"Klinkhammer","sequence":"first","affiliation":[{"name":"University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs075"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.348"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000424"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/478597"},{"key":"R5","first-page":"2202\u20132212","article-title":"ACE Inhibitor Myocardial Infarction Collaborative Group Indications for ACE inhibitors in the early treatment of acute myocardial infarction: systematic overview of individual data from 100,000 patients in randomized trials","volume":"97","year":"1998","journal-title":"Circulation"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009096.pub2"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.7326\/M13-1505"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700456"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311738"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002909"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.376"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs255"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18077"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.10.067"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.12.124"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007477"},{"key":"R18","first-page":"1","article-title":"Cardiovascular risk reduction by reversing endothelial dysfunction: ARBs, ACE inhibitors, or both? 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