{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:37:23Z","timestamp":1778081843543,"version":"3.51.4"},"reference-count":6,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["journals.sbmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Lasers Med Sci"],"abstract":"<jats:p>\n            <jats:bold>Introduction:<\/jats:bold> Melasma is one of the most common skin pigmentation disorders, which mostly affects the facial skin and has a considerable psychological impact on the patients. Melasma management has been one of the controversial issues in dermatology. We aimed to compare the combined treatment of the Er: YAG (erbium: yttrium\u2013aluminum\u2013garnet) laser plus hydroquinone (HQ) 4% with HQ 4% alone in the treatment of melasma. <jats:bold>Methods:<\/jats:bold> Twenty-nine patients were treated with the combined Er: YAG laser and HQ 4% on one side of the face with HQ 4% alone on the other side. Three sessions of the laser rat 4-week intervals. The outcome was calculated using the Melasma Area Severity Index (MASI). <jats:bold>Results:<\/jats:bold> The side that received the combined treatment (laser + HQ 4%) showed a statistically significant reduction in MASI compared to the side treated with HQ 4% alone. <jats:bold>Conclusion:<\/jats:bold> Our study suggests the superiority of the combination of the Er: YAG laser and HQ 4% in the treatment of melasma compared to HQ 4% alone.<\/jats:p>","DOI":"10.15171\/jlms.2020.12","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T09:32:20Z","timestamp":1581327140000},"page":"70-73","update-policy":"https:\/\/doi.org\/10.15171\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Split-Face Comparison of the Combined Er-YAG Laser and Hydroquinone 4% With Hydroquinone 4% Alone in the Treatment of Melasma in Iranian Patients: A Prospective, Interventional Case Study"],"prefix":"10.34172","volume":"11","author":[{"given":"Nastaran","family":"Namazi","sequence":"first","affiliation":[{"name":"Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Hesami","sequence":"additional","affiliation":[{"name":"Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-9391","authenticated-orcid":true,"given":"Yasaman","family":"Ketabi","sequence":"additional","affiliation":[{"name":"Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2020,1,18]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20143063"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962013000200009"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04430.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08103.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12477"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/158241"}],"container-title":["Journal of Lasers in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sbmu.ac.ir\/jlms\/article\/download\/25694\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sbmu.ac.ir\/jlms\/article\/download\/25694\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T15:25:00Z","timestamp":1585236300000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sbmu.ac.ir\/jlms\/article\/view\/25694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,18]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.15171\/jlms.2020.12","relation":{},"ISSN":["2008-9783","2228-6721"],"issn-type":[{"value":"2008-9783","type":"print"},{"value":"2228-6721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,18]]},"assertion":[{"value":"Laser Application in Medical Sciences Research Center","name":"journal_owner","label":"Journal Owner"},{"value":"Laser Application in Medical Sciences Research Center","name":"journal_publisher","label":"Journal Publisher"}]}}