{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:04:57Z","timestamp":1762999497598,"version":"3.37.3"},"reference-count":17,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["joddd.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Dent Res Dent Clin Dent Prospects"],"abstract":"<jats:p>Background. The ultimate aim of periodontal treatment is to regenerate periodontium and regenerative treatment after that. The aim of this study was to evaluate the effect of PRGF with 1% metformin biofilm in the treatment of two-wall intrabony periodontal defects.  Methods. In this clinical trial, 8 patients with moderate chronic periodontitis and two-wall intrabony defect were selected. The defects were assigned to 4 groups: debridement, 1% metformin, PRGF, PRGF and metformin. The parameters of vertical probing depth, vertical clinical attachment level and gingival index were measured at baseline, immediately before surgery, and 3 and 6 months after surgery. In addition, the radiographic changes were evaluated with digital subtraction radiography before and 6 months after surgery. Analysis of the results was performed with repeated measurements, Friedman test and chisquared test.  Results. All the groups exhibited improvements in all the clinical parameters after 6 months. Inter-group comparison of GI, CAL and PPD parameters revealed no statistically significant differences. Radiographic changes in the group of 1% metformin with PRGF revealed statistically significant differences compared with other groups; however, there were no statistically significant differences in other groups.  Conclusion. Application of PRGF with 1% metformin in intrabony two-wall periodontal defects was effective in improving the clinical parameters but this effect revealed no difference compared with other groups; however, in terms of radiographic changes significant improvements were noted.<\/jats:p>","DOI":"10.15171\/joddd.2019.008","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T03:32:36Z","timestamp":1560742356000},"page":"51-56","update-policy":"https:\/\/doi.org\/10.15171\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and radiographic evaluation of applying 1% metformin biofilm with plasma rich in growth factor (PRGF) for treatment of two-wall intrabony periodontal defects: A randomized clinical trial"],"prefix":"10.34172","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1476-4928","authenticated-orcid":true,"given":"Shabnam","family":"Khalifehzadeh","sequence":"first","affiliation":[{"name":"Student Research Committee, Babol University of Medical Sciences, Babol, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Haghanifar","sequence":"additional","affiliation":[{"name":"Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloofar","family":"Jenabian","sequence":"additional","affiliation":[{"name":"Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohrab","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Research Center Institute, Babol University of Medical Sciences, Babol, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Hajiahmadi","sequence":"additional","affiliation":[{"name":"Department Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"R1","unstructured":"Newman MG, Takei HH, Klokkevold PR, Carranza FA. 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