{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:13:38Z","timestamp":1788891218161,"version":"build-2803163510"},"reference-count":113,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["mejdd.org"],"crossmark-restriction":false},"short-container-title":["Middle East J Dig Dis"],"DOI":"10.15171\/mejdd.2016.34","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T21:44:20Z","timestamp":1481233460000},"page":"249-266","update-policy":"https:\/\/doi.org\/10.15171\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Esophageal Cancer in Golestan Province, Iran: A Review of Genetic Susceptibility and Environmental Risk Factors"],"prefix":"10.34172","volume":"8","author":[{"given":"Mahin","family":"Gholipour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Islami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Roshandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Khoshnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Badakhshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolvahab","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Malekzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2010.03.002"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers2031379"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601737"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022152"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.09.018"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Blot WJ MJ, Fraumeni JF. Esophageal Cancer. In: Schottenfeld D FJ, eds, editor. Cancer Epidemiology and Prevention. Oxford:Oxford University Press 2006. p. 697-706.","DOI":"10.1093\/acprof:oso\/9780195149616.003.0036"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350505"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2005.11.002"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(99)00054-2"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0437"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Schottenfeld D. Cancer epidemiology and prevention: Oxford University Press; 2006. doi: 10.1093\/acprof:oso\/9780195149616.001.0001.","DOI":"10.1093\/acprof:oso\/9780195149616.001.0001"},{"key":"R13","unstructured":"Roshandel G, Sadjadi A, Aarabi M, Keshtkar A, Sedaghat SM, Nouraie SM, et al. Cancer incidence in Golestan Province: report of an ongoing population-based cancer registry in Iran between 2004 and 2008. Arch Iran Med 2012;15:196-200."},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21906"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.17795\/jjcdc-33229"},{"key":"R16","unstructured":"Etemadi A, Abnet CC, Golozar A, Malekzadeh R, Dawsey SM. Modeling the Risk of Esophageal Squamous Cell Carcinoma and Squamous Dysplasia in a High Risk Area in Iran. Arch Iran Med 2012;15:18-21."},{"key":"R17","unstructured":"Marmot M, Atinmo T, Byers T, Chen J, Hirohata T, Jackson A, et al. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. 2007."},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602249"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b929"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.5732\/cjc.011.10390"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp161"},{"key":"R22","unstructured":"Kamangar F, Malekzadeh R, Dawsey SM, Saidi F. Esophageal cancer in Northeastern Iran: a review. Arch Iran Med 2007;10:70-82."},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20616"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604369"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e2502"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0b013e31823f5fa7"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp195"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12210"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.2.114"},{"key":"R30","first-page":"1013","article-title":"Measurement of socioeconomic status in health disparities research","volume":"99","author":"Shavers VL","year":"2007","journal-title":"J Natl Med Assoc"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2010.10.011"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1410"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8072675"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2013.779384"},{"key":"R35","first-page":"425","article-title":"High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran","volume":"25","author":"Kamangar F","year":"2005","journal-title":"Anticancer Res"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1080\/01635580701684831"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2012.00014"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1094\/Phyto-82-353"},{"key":"R39","unstructured":"IARC. IARC Monographs on the evaluation ofcarcinogenic risks t o humans. Lyon,France International Agency for Research on Cancer (IARC), 2002."},{"key":"R40","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.7314\/APJCP.2012.13.6.2625","article-title":"Alizadeh ARoudbarmohammadi SFumonisin B1 Contamination of Cereals and Risk of Esophageal Cancer in a High Risk Area in Northeastern Iran","volume":"13","author":"Alizadeh A","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.01.010"},{"key":"R42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-474X(88)90007-0","article-title":"The microbiology of cereal grains from areas of Iran with a high incidence of oesophageal cancer","volume":"24","author":"Lacey J","year":"1988","journal-title":"J Stored Prod Res"},{"key":"R43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3920\/WMJ2011.1337","article-title":"A pilot survey for Fusarium mycotoxin biomarkers in women from Golestan, Northern Iran","volume":"5","author":"Turner P","year":"2012","journal-title":"World Myco J"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1080\/01635580902803735"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0558"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.332"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21871"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.10.721"},{"key":"R50","first-page":"19","article-title":"Detection of human papillomavirus DNA by PCR in esophageal squamous cell carcinoma from Turkmen Sahra, north-east of Iran","volume":"6","author":"Moradi A","year":"2002","journal-title":"Iran Biomed J"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.3923\/ijcr.2006.113.118"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr499"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0934"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-016-0049-x"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143603"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-10"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0109"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1774-z"},{"key":"R59","doi-asserted-by":"crossref","unstructured":"Rastgar Jazii F. Esophageal cancer - cell and molecular biology , biomarkers,nutrition and treatment: Janeza Trdine 9, 51000 Rijeka, Croatia 2012. 254.","DOI":"10.5772\/1196"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0135"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032003000400011"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(00)00019-3"},{"key":"R63","first-page":"","article-title":"Evaluation of cyclin d1 expression in esophageal squamous cell carcinoma and its effect on response rate to neo-adjuvant chemoradiotherapy","author":"Ghavam Nasiri M","year":"2010","journal-title":"Iran J Pathol"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0700-5"},{"key":"R65","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.7314\/APJCP.2014.15.14.5889","article-title":"Relationship between EGFR Over-expression and Clinicopathologic Characteristics in Squamous Cell Carcinoma of the Esophagus: A Meta-analysis","volume":"15","author":"Wang J","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-602"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209367"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-004-2885-3"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10081"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2000.tb00931.x"},{"key":"R72","first-page":"111","article-title":"Prevalence of Esophageal Cancer Risk Factors among Turkmen and Non-Turkmen Ethnic Groups in a High Incidence Area in Iran","volume":"13","author":"Marjani HA BF","year":"2010","journal-title":"Arch Iran Med"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029488"},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1110(96)90017-2"},{"key":"R75","first-page":"235","article-title":"P21 (Waf1\/Cip1)Gene Polymorphisms and Possible Interaction with Cigarette Smoking in Esophageal Squamous Cell Carcinoma in Northeastern Iran: A Preliminary Study","volume":"13","author":"Taghavi N BF","year":"2010","journal-title":"Arch Iran Med"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-138"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb02195.x"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210739"},{"key":"R79","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27953"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-010-0056-7"},{"key":"R81","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-1098"},{"key":"R82","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.05.017"},{"key":"R83","first-page":"375","article-title":"Epidemiology of Esophageal Cancer in the High-Risk Population","volume":"7","author":"Mosavi -Jarrahi A MM","year":"2006","journal-title":"Asian Pacific J Cancer Prev"},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1149"},{"key":"R85","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2012.00014"},{"key":"R86","doi-asserted-by":"crossref","unstructured":"Shimada T. Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. Drug Metab Pharmacokinet 2006;21:257-76. doi :10.2133\/dmpk.21.257.","DOI":"10.2133\/dmpk.21.257"},{"key":"R87","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-14-31"},{"key":"R88","doi-asserted-by":"publisher","DOI":"10.4238\/vol9-1gmr693"},{"key":"R89","first-page":"1622","article-title":"Semiquantitation of polycyclic aromatic hydrocarbon-DNA adducts in human esophagus by immunohistochemistry and the automated cellular imaging system","volume":"11","author":"van Gijssel HE","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R90","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-0951-7"},{"key":"R91","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1864-y"},{"key":"R92","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/S0959-8049(00)00297-5","article-title":"Gelatinolytic activity of matrix metalloproteinase-2 and -9 in oesophageal carcinoma; a study using in situ zymography","volume":"36","author":"Koyama H","year":"2000","journal-title":"Eur J Cancer"},{"key":"R93","first-page":"63","article-title":"4,4[prime]-Methylene-bis(2-chloroaniline)-DNA adduct analysis in human exfoliated urothelial cells by 32P-postlabeling","volume":"2","author":"Kaderlik KR","year":"1993","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R94","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970501)79:9<1647:AIDAIDCNCR3>3.0.CO;2-9"},{"key":"R95","doi-asserted-by":"publisher","DOI":"10.1021\/pr200141c"},{"key":"R96","doi-asserted-by":"publisher","DOI":"10.1080\/03008200802148462"},{"key":"R97","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3628"},{"key":"R98","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.07.018"},{"key":"R99","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i44.7104"},{"key":"R100","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25330"},{"key":"R101","doi-asserted-by":"publisher","DOI":"10.1159\/000310918"},{"key":"R102","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs204"},{"key":"R103","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472"},{"key":"R104","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1467"},{"key":"R105","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-1051-6"},{"key":"R106","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2854-z"},{"key":"R107","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032711"},{"key":"R108","first-page":"220","article-title":"Expression of Cyclin D1 and P16 in Esophageal Squamous Cell Carcinoma","volume":"7","author":"Dey B","year":"2015","journal-title":"Middle East J Dig Dis"},{"key":"R109","first-page":"3119","article-title":"Unusual profile and high prevalence of p53 mutations in esophageal squamous cell carcinomas from northern Iran","volume":"61","author":"Biramijamal F","year":"2001","journal-title":"Cancer Res"},{"key":"R110","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i39.4958"},{"key":"R111","first-page":"3501","article-title":"Expression of p53 and p21 and the clinical response for hyperthermochemoradiotherapy in patients with squamous cell carcinoma of the esophagus","volume":"27","author":"Ishida M","year":"2007","journal-title":"Anticancer Res"},{"key":"R112","doi-asserted-by":"publisher","DOI":"10.6133\/apjcn.2014.23.3.11"},{"key":"R113","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.523"}],"container-title":["Middle East Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/mejdd.org\/files\/journals\/9\/articles\/1682\/public\/1682-6069-1-PB.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T21:08:26Z","timestamp":1581714506000},"score":1,"resource":{"primary":{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/view\/1682.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":113,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,12]]}},"URL":"https:\/\/doi.org\/10.15171\/mejdd.2016.34","relation":{},"ISSN":["2008-5230","2008-5249"],"issn-type":[{"value":"2008-5230","type":"print"},{"value":"2008-5249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,1]]}}}