{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:18:10Z","timestamp":1790338690986,"version":"4.1.0"},"reference-count":37,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["mejdd.org"],"crossmark-restriction":false},"short-container-title":["Middle East J Dig Dis"],"abstract":"<jats:p>BACKGROUND  Cytomegalovirus (CMV) infection is common in individuals with inflammatory bowel disease (IBD) and is responsible for relapse, increased severity, and poor outcome if left untreated. Ganciclovir is the mainstay of treatment but data regarding its use, mode of administration, and duration of treatment is poorly described. We reviewed the practice of treating CMV colitis with different regimes of ganciclovir at a district NHS hospital to compare the clinical outcome.  METHODS  35 patients with IBD and concurrent diagnosis of CMV infection were evaluated. The parameters studied were clinical outcome in term of clinical response, length of hospital stay, readmission, or colectomy with three different regimes of ganciclovir, in addition to treatment for IBD.  RESULTS  35 patients with IBD (ulcerative colitis = 23, Crohn\u2019s disease = 5, Indeterminate colitis = 7) and positive diagnosis of CMV infection were studied. Clinical outcome with two weeks of intravenous (IV) ganciclovir regime was superior than one week of IV ganciclovir and two weeks of oral Valganciclovir in term of clinical response on day 15 (95.8% vs 74%, 24.3%, respectively p = 0.45) and colectomy rate within 3 months (6.25% vs 27.3%, vs 25%, respectively).  CONCLUSION  CMV colitis is associated with poor outcome in patient with IBD if left untreated. 2 weeks IV ganciclovir was associated with a better outcome than 1 week of IV treatment or oral treatment. <\/jats:p>","DOI":"10.15171\/mejdd.2018.114","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T12:40:24Z","timestamp":1544100024000},"page":"220-229","update-policy":"https:\/\/doi.org\/10.15171\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Outcome of Cytomegalovirus Colitis in Inflammatory Bowel Disease with Different Regimes of Ganciclovir"],"prefix":"10.34172","volume":"10","author":[{"given":"Iftikhar","family":"Ahmed","sequence":"first","affiliation":[{"name":"School of Medicine, University of Southampton, UK"},{"name":"Department of Medicine, Aldara Hospital and Medical Centre, Riyadh, KSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Kassem","sequence":"additional","affiliation":[{"name":"Department of Medicine, Aldara Hospital and Medical Centre, Riyadh, KSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazen","family":"Salam","sequence":"additional","affiliation":[{"name":"School of Medicine, Alfaisal University, Riyadh, KSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuele","family":"Furnari","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Royal United Hospital Bath, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12006"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000148239.00384.F0"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-012-0266-4"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00869.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1126-4"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0639-6"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200405000-00011"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.05.013"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000028"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2212-x"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31829df29d"},{"key":"R12","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S1386-6532(02)00091-4","article-title":"Diagnosis and treatment approaches of CMV infections in adult patients","volume":"25 Suppl 2","author":"de la Hoz RE","year":"2002","journal-title":"J Clin Virol"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2009.11.004"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182160c9c"},{"key":"R15","unstructured":"European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in IBD, ECCO guidelines, 2009."},{"key":"R16","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1111\/j.1572-0241.2001.03949.x","article-title":"Outcome of cytomegalovirus infections in patients with inflammatory bowel disease","volume":"96","author":"Papadakis KA","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21275"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i3.1321"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13124"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.5009\/gnl13427"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0639-6"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2828-1"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652008000200004"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/282507"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.202"},{"key":"R26","first-page":"S","article-title":"Colectomy rates for patients treated for CMV disease in the context of Ulcerative Colitis do not differ from those who are not treated for CMV disease","volume":"138","author":"Zeki SS","year":"2010","journal-title":"Gastroenterology"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00989.x"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00091-4"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.2.373"},{"key":"R30","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1128\/JCM.36.9.2509-2513.1998","article-title":"Evaluation of the AMPLICOR cytomegalovirus test with specimens from human immunodeficiency virus-infected subjects","volume":"36","author":"Boivin G","year":"1998","journal-title":"J Clin Microbiol"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1097\/01.DCR.0000087486.21981.C6"},{"key":"R32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00004836-200203000-00010","article-title":"Cytomegalovirus enterocolitis in an immunocompetent individual","volume":"34","author":"Sakamoto I","year":"2002","journal-title":"J Clin Gastroenterol"},{"key":"R33","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3748\/wjg.v16.i10.1245","article-title":"Specific endoscopic features of ulcerative colitis complicated by cytomegalovirus infection","volume":"16","author":"Suzuki H","year":"2010","journal-title":"World J Gastroenterol"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.114955"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00382.x"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01910.x"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02617.x"}],"container-title":["Middle East Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/download\/1990\/2083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/download\/1990\/2083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T12:05:27Z","timestamp":1585137927000},"score":1,"resource":{"primary":{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/view\/1990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.15171\/mejdd.2018.114","relation":{},"ISSN":["2008-5249"],"issn-type":[{"value":"2008-5249","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,5]]},"assertion":[{"value":"Iranian Association of Gastroenterology and Hepatology","name":"journal_owner","label":"Journal Owner"},{"value":"Iranian Association of Gastroenterology and Hepatology","name":"journal_publisher","label":"Journal Publisher"}]}}