{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:21:52Z","timestamp":1789924912751,"version":"4.0.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1519\/jsc.0b013e3181c4d370","type":"journal-article","created":{"date-parts":[[2010,11,6]],"date-time":"2010-11-06T01:51:46Z","timestamp":1289008306000},"page":"531-537","source":"Crossref","is-referenced-by-count":34,"title":["Exercise-Induced Muscle Damage Is Not Attenuated by \u03b2-Hydroxy-\u03b2-Methylbutyrate and \u03b1-Ketoisocaproic Acid Supplementation"],"prefix":"10.1519","volume":"24","author":[{"given":"David","family":"Nunan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glyn","family":"Howatson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken A","family":"van Someren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-34-20210210","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2519\/jospt.1991.13.3.138","article-title":"Baltzopoulas, V, Williams, JD, and Brodie, DA. Sources of error in isokinetic dynamometry: Effects of visual feedback on maximum torque measurements.","volume":"13","year":"1991","journal-title":"J Orthop Sports Phys Ther"},{"key":"R2-34-20210210","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2165\/00007256-200737060-00005","article-title":"The role of nutritional supplements in the prevention and treatment of resistance exercise-induced skeletal muscle injury.","volume":"37","author":"Bloomer","year":"2007","journal-title":"Sports Med"},{"key":"R3-34-20210210","doi-asserted-by":"crossref","first-page":"S263","DOI":"10.1097\/00005768-199905001-01272","article-title":"Byrd, PL, Mehta, PM, Devita, P, Dyck, D, and Hickner, RC. Changes in muscle soreness and strength following downhill running: Effects of creatine, HMB, and betagen supplementation [Abstract].","volume":"31","year":"1999","journal-title":"Med Sci Sports Exerc"},{"key":"R5-34-20210210","first-page":"512","article-title":"Clarkson, PM, Nosaka, K, and Braun, B. Muscle function after exercise-induced muscle damage and rapid adaptation.","volume":"24","year":"1992","journal-title":"Med Sci Sports Exerc"},{"key":"R6-34-20210210","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/02640419608727714","article-title":"Eston, RG, Finney, S, Baker, A, and Baltzopoulos, V. Muscle tenderness and peak torque changes after downhill running following a prior bout of isokinetic eccentric exercise.","volume":"14","year":"1996","journal-title":"J Sports Sci"},{"key":"R7-34-20210210","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1034\/j.1600-0838.2000.010004199.x","article-title":"Eston, RG, Lemmey, AB, McHugh, MP, Byrne, C, and Walsh, SE. Effect of stride length on symptoms of exercise induced muscle damage during a repeated bout of downhill running.","volume":"10","year":"2000","journal-title":"Scand J Med Sci Sports"},{"key":"R9-34-20210210","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1097\/00005768-200012000-00022","article-title":"Gallagher, PM, Carrithers, JA, Godard, MP, Schulze, KE, and Trappe, SW. -hydroxy--methylbutyrate ingestion, Part 1: Effects on strength and fat free mass.","volume":"32","year":"2000","journal-title":"Med Sci Sports Exerc"},{"key":"R10-34-20210210","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1055\/s-2007-964866","article-title":"Howatson, G, Van Someren, KA, and Hortobagyi, T. Repeated bout effect after maximal eccentric exercise.","volume":"28","year":"2007","journal-title":"Int J Sports Med"},{"key":"R11-34-20210210","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1152\/jappl.2000.89.4.1340","article-title":"Knitter, AE, Panton, L, Rathmacher, JA, Peterson, A, and Sharp, R. Effects of -hydroxy--methylbutyrate on muscle damage after a prolonged run.","volume":"89","year":"2000","journal-title":"J Appl Physiol"},{"key":"R12-34-20210210","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1055\/s-1999-8835","article-title":"Kreider, RB, Ferreira, M, Wilson, M, and Almada, AL. Effects of calcium -hydroxy--methylbutyrate (HMB) supplementation during resistance training on markers of catabolism, body composition and strength.","volume":"20","year":"1999","journal-title":"Int J Sports Med"},{"key":"R13-34-20210210","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1034\/j.1600-0838.2003.02477.x","article-title":"Recent advances in the understanding of the repeated bout effect: The protective effect against muscle damage from a single bout of eccentric exercise.","volume":"13","author":"McHugh","year":"2003","journal-title":"Scand J Med Sci Sports"},{"key":"R14-34-20210210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/mus.880090109","article-title":"Newham, DJ, Jones, DA, and Edwards, RHT. Plasma creatine kinase changes after eccentric and concentric contractions.","volume":"9","year":"1986","journal-title":"Muscle Nerve"},{"key":"R15-34-20210210","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0955-2863(97)00048-X","article-title":"Nissen, S and Abumrad, N. Nutritional role of the leucine metabolite -hydroxy--methylbutyrate (HMB).","volume":"8","year":"1997","journal-title":"J Nutr Biochem"},{"key":"R16-34-20210210","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1152\/jappl.1996.81.5.2095","article-title":"Nissen, S, Sharp, R, Ray, M, Rathmacher, JA, Rice, D, Fuller, JC Jr, Connelly, AS, and Abumrad, N. The effect of leucine metabolite -hydroxy--methylbutyrate on muscle metabolism during resistance exercise training.","volume":"81","year":"1996","journal-title":"J Appl Physiol"},{"key":"R17-34-20210210","first-page":"1263","article-title":"Nosaka, K, and Clarkson, PM. Muscle damage following repeated bouts of high force eccentric exercise.","volume":"27","year":"1995","journal-title":"Med Sci Sports Exerc"},{"key":"R18-34-20210210","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1097\/00005768-200109000-00011","article-title":"Nosaka, K, Sakamoto, K, Newton, M, and Sacco, P. How long does the protective effect on eccentric exercise-induced muscle damage last?","volume":"33","year":"2001","journal-title":"Med Sci Sports Exerc"},{"key":"R19-34-20210210","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1123\/ijsnem.11.4.442","article-title":"Jones, D, Keech, A, and Jenkins, D. Short-term beta-hydroxy-beta-methylbutyrate supplementation does not reduce symptoms of eccentric muscle damage.","volume":"11","year":"2001","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"R20-34-20210210","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0899-9007(00)00376-2","article-title":"Panton, LB, Rathmacher, JA, Baier, S, and Nissen, S. Nutritional supplementation of the leucine metabolite -hydroxy--methylbutyrate (HMB) during resistance training.","volume":"16","year":"2000","journal-title":"Nutrition"},{"key":"R21-34-20210210","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1123\/ijsnem.11.3.384","article-title":"Slater, G, Jenkins, D, Logan, P, Lee, H, Vukovich, M, Rathmacher, JA, and Hahn, AG. -hydroxy--methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men.","volume":"11","year":"2001","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"R22-34-20210210","first-page":"E27","article-title":"Koevering, M and Nissen, S. Oxidation of leucine and -ketoisocaproate to -hydroxy--methylbutyrate in vivo.","volume":"262","year":"1992","journal-title":"Am J Physiol"},{"key":"R23-34-20210210","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1123\/ijsnem.15.4.413","article-title":"Someren, KA, Edwards, AJ, and Howatson, G. Supplementation with -hydroxy--methylbutyrate (HMB) and -ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man.","volume":"15","year":"2005","journal-title":"Int J Sport Nutr Exerc Metab"}],"container-title":["Journal of Strength and Conditioning Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00124278-201002000-00034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T18:39:38Z","timestamp":1786127978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00124278-201002000-00034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1519\/jsc.0b013e3181c4d370","relation":{},"ISSN":["1064-8011"],"issn-type":[{"value":"1064-8011","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}