{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:00:52Z","timestamp":1779184852661,"version":"3.51.4"},"reference-count":17,"publisher":"Guilford Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Education and Prevention"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p> We triangulated quantitative and qualitative assessments to evaluate participants\u2019 acceptability of 0.05% dapivirine rectal microbicide (RM) gel administered via two separate modalities (a rectal applicator and an artificial phallus for use as a coital simulation device) as part of a Phase I trial (N = 14) among men who have sex with men (MSM) randomized using a 1:1 ratio. Overall, participants reported favorable acceptability of the gel (n = 11; 78.6%), the same or more at the end of the study compared to when they started the study. Additionally, when discussing their preferred administration modality, they noted that both methods had positive qualities but also potential areas of improvement. Our findings underscore the need to create multiple delivery methods for a future microbicide gel (i.e., with and without the need for an applicator) and highlight the importance of offering MSM choices in how biomedical HIV prevention strategies are delivered. <\/jats:p>","DOI":"10.1521\/aeap.2021.33.5.361","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T14:32:28Z","timestamp":1633098748000},"page":"361-376","source":"Crossref","is-referenced-by-count":7,"title":["Acceptability of a Dapivirine Gel Administered Rectally to HIV-1 Seronegative Adults (MTN-033 Study)"],"prefix":"10.1521","volume":"33","author":[{"given":"Jos\u00e9 A.","family":"Bauermeister","sequence":"first","affiliation":[{"name":"University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan C.","family":"Tingler","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherri","family":"Johnson","sequence":"additional","affiliation":[{"name":"FHI 360, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Macagna","sequence":"additional","affiliation":[{"name":"FHI 360, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Lucas","sequence":"additional","affiliation":[{"name":"FHI 360, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Dominguez-Islas","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Szydlo","sequence":"additional","affiliation":[{"name":"Statistical Center for HIV\/AIDS Research & Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Ngo","sequence":"additional","affiliation":[{"name":"Statistical Center for HIV\/AIDS Research & Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy E.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Kramzer","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devika","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlene S.","family":"Dezzutti","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, Pennsylvania."},{"name":"Microbicide Trials Network, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratiya Pamela Kunjara","family":"Na Ayudhya","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanna","family":"Piper","sequence":"additional","affiliation":[{"name":"Division of AIDS\/NIAID\/NIH, Bethesda, Maryland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Br\u00edd","family":"Devlin","sequence":"additional","affiliation":[{"name":"International Partnership for Microbicides, Silver Spring, Maryland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig W.","family":"Hendrix","sequence":"additional","affiliation":[{"name":"Microbicide Trials Network, Pittsburgh, Pennsylvania."},{"name":"Johns Hopkins University School of Medicine, Baltimore, Maryland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ho","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the MTN-033 Protocol Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"377","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1521\/aeap.2016.28.1.1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.030478"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000233715.59239.83"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-014-0768-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-014-0793-0"},{"issue":"5","key":"ref8","first-page":"614","volume":"64","author":"Cranston R. 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