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Statistical analyses explored associations between demographic factors and barriers to PrEP. While 81% had heard of PrEP, nearly half were unaware of HIV testing requirements or of its availability for uninsured individuals. Uninsured participants were significantly less comfortable discussing sexual health with providers (OR: 0.19, 95% CI [0.05, 0.68]). Addressing misinformation, reducing provider stigma, and expanding access for uninsured individuals are essential for increasing PrEP use. <\/jats:p>","DOI":"10.1521\/aeap.2025.37.2.126","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T16:04:52Z","timestamp":1746461092000},"page":"126-141","source":"Crossref","is-referenced-by-count":0,"title":["Knowledge and Barriers to HIV Pre-exposure Prophylaxis in Southern California"],"prefix":"10.1521","volume":"37","author":[{"given":"Gilbert A.","family":"Orta Portillo","sequence":"first","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrysovalantis","family":"Stafylis","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara","family":"Tapia","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Klausner","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California."},{"name":"Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"377","reference":[{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-021-03262-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1521\/aeap.2018.30.1.1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157324"},{"issue":"3","key":"ref13","volume":"28","author":"Centers for Disease Control and Prevention","year":"2023","journal-title":"HIV Surveillance Supplemental Report"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-022-08730-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177\/00469580211017666"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2021.0236"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-022-03656-y"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184014"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-016-1353-6"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2017.0082"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/2331205X.2018.1475124"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1017\/jme.2022.37"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6837a2"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2019.305389"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001140"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2019.01.003"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152361"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.17294\/2330-0698.1737"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01295-0"},{"issue":"5","key":"ref34","first-page":"155798832312017","volume":"17","author":"Moyo P. 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