{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:02:43Z","timestamp":1780938163415,"version":"3.54.1"},"reference-count":29,"publisher":"Guilford Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bulletin of the Menninger Clinic"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Aim: To exploratively describe long-term psychiatric and behavioral symptoms in pediatric survivors of herpes simplex virus type 1 encephalitis. Methods: In this retrospective descriptive case series conducted at two tertiary pediatric centers, admissions from 2000 to 2022 were screened for confirmed herpes simplex virus type 1 encephalitis. Eight families completed validated parentand self-report questionnaires assessing emotional and behavioral symptoms. Analyses were descriptive. Results: Mean age at disease onset was 5.4 years, and mean age at follow-up was 13.1 years. Seven of eight children exhibited persistent neurological sequelae. Clinically elevated emotional or behavioral symptoms were observed in a subset of children, including anxiety, depressive symptoms, and attention problems. Conclusions: Some pediatric survivors exhibited clinically relevant emotional and behavioral symptoms years after the acute illness. Although no conclusions regarding prevalence or disease-specific risk can be drawn, the findings underscore the importance of clinical awareness and mental health screening as part of long-term follow-up care.<\/jats:p>","DOI":"10.1521\/bumc.2026.90.2.126","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:44:21Z","timestamp":1780937061000},"page":"126-143","source":"Crossref","is-referenced-by-count":0,"title":["Psychiatric and behavioral symptoms after pediatric herpes simplex virus type 1 encephalitis: An exploratory case series"],"prefix":"10.1521","volume":"90","author":[{"given":"Patrick","family":"Galland","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Children's Hospital Auf der Bult Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Children's Hospital Auf der Bult Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenike","family":"Steven","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Children's Hospital Auf der Bult Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Hilfrich","sequence":"additional","affiliation":[{"name":"Professor Emeritus of Pathology and Gynecology, formerly at Eilenriedeklinik, Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Rahn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"377","reference":[{"key":"ref1","volume-title":"Manual for the ASEBA school-age forms & profiles.","author":"Achenbach T.","year":"2001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad238"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Asogwa, K., Buabeng, K. & Kaur, A. 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(2000). Depressionsinventar f\u00fcr Kinder und Jugendliche (DIKJ) [Depression Inventory for Children and Adolescents (DIKJ)]. Hogrefe."},{"key":"ref28","first-page":"68","volume":"3","author":"Tottenham N.","year":"2009","journal-title":"Frontiers in Human Neuroscience"},{"issue":"2","key":"ref29","first-page":"57A","volume":"11","author":"Tyler K. 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