{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:35:49Z","timestamp":1792226149711,"version":"4.4.0"},"reference-count":133,"publisher":"Society for Neuroscience","issue":"4","funder":[{"DOI":"10.13039\/501100002426","name":"Telethon Foundation","doi-asserted-by":"crossref","award":["GGP09066"],"award-info":[{"award-number":["GGP09066"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["eneuro"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>REST [RE1-silencing transcription factor (also called neuron-restrictive silencer factor)] is known to repress thousands of possible target genes, many of which are neuron specific. To date, REST repression has been investigated mostly in stem cells and differentiating neurons. Current evidence demonstrates its importance in adult neurons as well. Low levels of REST, which are acquired during differentiation, govern the expression of specific neuronal phenotypes. REST-dependent genes encode important targets, including transcription factors, transmitter release proteins, voltage-dependent and receptor channels, and signaling proteins. Additional neuronal properties depend on miRNAs expressed reciprocally to REST and on specific splicing factors. In adult neurons, REST levels are not always low. Increases occur during aging in healthy humans. Moreover, extensive evidence demonstrates that prolonged stimulation with various agents induces REST increases, which are associated with the repression of neuron-specific genes with appropriate, intermediate REST binding affinity. Whether neuronal increases in REST are protective or detrimental remains a subject of debate. Examples of CA1 hippocampal neuron protection upon depolarization, and of neurodegeneration upon glutamate treatment and hypoxia have been reported. REST participation in psychiatric and neurological diseases has been shown, especially in Alzheimer\u2019s disease and Huntington\u2019s disease, as well as epilepsy. Distinct, complex roles of the repressor in these different diseases have emerged. In conclusion, REST is certainly very important in a large number of conditions. We suggest that the conflicting results reported for the role of REST in physiology, pathology, and disease depend on its complex, direct, and indirect actions on many gene targets and on the diverse approaches used during the investigations.<\/jats:p>","DOI":"10.1523\/eneuro.0010-15.2015","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T04:00:33Z","timestamp":1435809633000},"page":"ENEURO.0010-15.2015","source":"Crossref","is-referenced-by-count":75,"title":["The Transcription Repressor REST in Adult Neurons: Physiology, Pathology, and Diseases"],"prefix":"10.1523","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3436","authenticated-orcid":false,"given":"Pietro","family":"Baldelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4022-1281","authenticated-orcid":false,"given":"Jacopo","family":"Meldolesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007936"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.072272"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.01.007"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.4","doi-asserted-by":"publisher","DOI":"10.1101\/gr.142661.112"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.03.013"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.08.015"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2013.11.004"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.8","doi-asserted-by":"publisher","DOI":"10.1042\/BST0371270"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401827101"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.02.003"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.02.059"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.12","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1523\/JNEUROSCI.23-06-02112.2003","article-title":"Ischemic insults derepress the gene silencer REST in neurons destined to die.","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.08.012"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.14","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1430"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.15","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90298-8"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511041103"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.17","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12348"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.18","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3668"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.19","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1749-6632.2008.03988.x","article-title":"Expression of dense-core vesicles and of their exocytosis are governed by the repressive transcription factor NRSF\/REST","volume":"1152","year":"2009","journal-title":"Ann N Y Sci"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.265173"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.21","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.147"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002494"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.23","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-007-9059-8"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.24","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.25","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00178"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.26","first-page":"167","article-title":"Extracellular signal-related kinase 2\/specificity protein 1\/specificity protein 3\/repressor element-1 silencing transcription factor pathways involved in Arochlor 1254-induced toxicity in SH-SY5Y neuronal cells","volume":"9","year":"2014","journal-title":"J Neurosci Res"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611704104"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1604-11.2011"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.29","doi-asserted-by":"publisher","DOI":"10.1038\/nn1791"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.30","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3482"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.31","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-47572013000100005"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.32","doi-asserted-by":"publisher","DOI":"10.2217\/fnl.09.1"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.33","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.24.6969"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140216"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.35","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0207"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.05.007"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.09.001"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.38","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq284"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03171.x"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.40","doi-asserted-by":"publisher","DOI":"10.1038\/13165"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.04.052"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.42","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2153"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2014.07.032"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.44","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0110-07.2007"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.04.027"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.46","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00059"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.47","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141319"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.10.035"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060256"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.50","first-page":"85","article-title":"Regulation of neural macroRNAs by the transcriptional repressor REST","volume":"5","year":"2009","journal-title":"RNA"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002624"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.52","doi-asserted-by":"publisher","DOI":"10.1242\/dev.028548"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2010.04.001"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.54","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4045-13.2014"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403633200"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.56","doi-asserted-by":"publisher","DOI":"10.1093\/nass\/49.1.87"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.57","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0809-1"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.58","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201974"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.599373"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.019"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.61","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp047"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.62","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gms023"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.63","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq184"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.64","doi-asserted-by":"publisher","DOI":"10.1038\/nature13163"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.08.001"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.09.003"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.67","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01267"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.68","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22479"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.02.008"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07626.x"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.71","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20080058"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.72","doi-asserted-by":"publisher","DOI":"10.1101\/gr.4997306"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.10.025"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.10.008"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.75","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1152\/jn.2002.88.1.409","article-title":"NRSF causes cAMP-sensitive suppression of sodium current in cultured hippocampal neurons.","volume":"88","year":"2002","journal-title":"J Neurophysiol"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.12.019"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.77","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20135116"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.01.006"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.79","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.09.158"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.80","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121568109"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.08.021"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.82","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2100"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.09.013"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.84","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0157-7"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.85","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0091-07.2007"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.86","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1523\/JNEUROSCI.18-04-01280.1998","article-title":"Neuronal expression of zinc finger transcription factor REST\/NRSF\/XBR gene.","volume":"18","year":"1998","journal-title":"J Neurosci"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.87","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.399782"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.22.12318"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.89","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa0069"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.90","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.231"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.91","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201010126"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.92","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.010751"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.93","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.014"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014311"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.95","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-014-0398-0"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.96","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3214"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.97","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12030"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.98","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2011.00008"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.99","doi-asserted-by":"crossref","unstructured":"Rusconi F , Paganini L , Braida D , Ponzoni L , Toffolo E , Maroli A , Landsberger N , Bedogni F , Turco E , Pattini L , Altruda F , De Biasi S , Sala M , Battaglioli E (2014) LSD1 neurospecific alternative splicing controls neuronal excitability in mouse models of epilepsy. Cereb Cortex. Advance online publication. Retrieved 2 July 2015. doi:10.1093\/cercor\/bhu070.","DOI":"10.1093\/cercor\/bhu070"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.100","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2897"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.101","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.6.3317"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.102","doi-asserted-by":"publisher","DOI":"10.1126\/science.7871435"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.103","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9587-2"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.104","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.12.080"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.105","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2011.04.008"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.106","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26145"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07122.x"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.108","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.04.020"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.109","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2012.12.007"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.110","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-07-0687"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.111","doi-asserted-by":"publisher","DOI":"10.1038\/nature05823"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.112","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0844-x"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.113","first-page":"347","article-title":"Actions of sodium valproate on the central nervous system.","volume":"50","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.114","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.12.021"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.115","doi-asserted-by":"publisher","DOI":"10.1038\/ng1610"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.116","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03434.x"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.117","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.310763"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.118","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3359"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.119","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.03.075"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.120","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000979"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.121","doi-asserted-by":"publisher","DOI":"10.1038\/nature06780"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.122","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.03.033"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.123","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-2-8"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.124","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-9-r85"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.125","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2013.06.001"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.126","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2934-09.2009"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.127","doi-asserted-by":"publisher","DOI":"10.1038\/nature08139"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.128","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2009.07.006"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.129","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.06.002"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.130","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2012.11.002"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.131","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.376590"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.132","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4278-06.2007"},{"key":"2023022708073655000_2.4.ENEURO.0010-15.2015.133","doi-asserted-by":"publisher","DOI":"10.1038\/ng1219"}],"container-title":["eneuro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0010-15.2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T16:10:54Z","timestamp":1677514254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eneuro.org\/lookup\/doi\/10.1523\/ENEURO.0010-15.2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":133,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,8,17]]},"published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1523\/ENEURO.0010-15.2015"],"URL":"https:\/\/doi.org\/10.1523\/eneuro.0010-15.2015","relation":{},"ISSN":["2373-2822"],"issn-type":[{"value":"2373-2822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}