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The synaptic impact of beta amyloid includes altered morphology and reduced number of dendritic spines at excitatory synapses, evident in the brains of individuals with Alzheimer\u2019s disease. Here, we assessed the ability of an identified neuroprotective peptide, YEVHHQ, derived from the N-terminal domain of A\u03b2, known as the A\u03b2Core, to protect against A\u03b2-induced alterations in dendritic spines. Our approach involved both 2D and 3D imaging of spine morphology in hippocampal neuron cultures from mice of either sex, with the 3D imaging focusing on the postsynaptic density (PSD), as its morphology is tightly correlated with synaptic strength, and presynaptic terminal morphology and density to assess the impact on both sides of the synapse. We present evidence for uniform prevention by the A\u03b2Core of A\u03b2-induced reductions in spine cross-sectional size and density as well as PSD surface area and volume. In addition, the A\u03b2Core alone increased the presynaptic terminal volume in parallel to the reversal of A\u03b2-induced changes in spine and PSD size. Together, these results provide support for reversal of structural changes underlying the functional reversal by the A\u03b2Core of A\u03b2-induced impairment of synaptic dynamics.<\/jats:p>","DOI":"10.1523\/eneuro.0044-25.2025","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T17:50:12Z","timestamp":1756144212000},"page":"ENEURO.0044-25.2025","update-policy":"https:\/\/doi.org\/10.1523\/eneuro.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["The Beta Amyloid Core Hexapeptide Protects against Full-Length Beta Amyloid-Induced Alteration of Dendritic Spine Morphology and Density"],"prefix":"10.1523","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0469-9955","authenticated-orcid":false,"given":"Ruth 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