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Recent spatiotemporal analyses suggest that \u03b1 oscillations support DMN functioning via interregional synchronization and sensory cortical inhibition. Therefore, we examined a unifying pathology of \u03b1 deficits in the visual-cortex-DMN system in PTSD. Human patients with PTSD (<jats:italic>N\u2009<\/jats:italic>=<jats:italic>\u2009<\/jats:italic>25) and two control groups, patients with generalized anxiety disorder (GAD;<jats:italic>N\u2009<\/jats:italic>=<jats:italic>\u2009<\/jats:italic>24) and healthy controls (HCs;<jats:italic>N\u2009<\/jats:italic>=<jats:italic>\u2009<\/jats:italic>20), underwent a standard eyes-open resting state (S-RS) and a modified resting state (M-RS) of passively viewing salient images (known to deactivate the DMN). High-density electroencephalogram (hdEEG) were recorded, from which intracortical \u03b1 activity (power and connectivity\/Granger causality) was extracted using the exact low-resolution electromagnetic tomography (eLORETA). Patients with PTSD (vs GAD\/HC) demonstrated attenuated \u03b1 power in the visual cortex (VC) and key hubs of the DMN [posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC)] at both states, the severity of which further correlated with hypervigilance symptoms. With increased visual input (at M-RS vs S-RS), patients with PTSD further demonstrated reduced \u03b1-frequency directed connectivity within the DMN (PCC\u2192mPFC) and, importantly, from the VC to both DMN hubs (VC\u2192PCC and VC\u2192mPFC), linking \u03b1 deficits in the two systems. These interrelated \u03b1 deficits align with DMN hypoactivity\/hypoconnectivity, sensory disinhibition, and hypervigilance in PTSD, representing a unifying neural underpinning of these anomalies. The identification of visual-cortex-DMN \u03b1 dysrhythmia in PTSD further presents a novel therapeutic target, promoting network-based intervention of neural oscillations.<\/jats:p>","DOI":"10.1523\/eneuro.0053-20.2020","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T21:45:13Z","timestamp":1595281513000},"page":"ENEURO.0053-20.2020","source":"Crossref","is-referenced-by-count":49,"title":["Posttraumatic Stress Disorder Is Associated with \u03b1 Dysrhythmia across the Visual Cortex and the Default Mode Network"],"prefix":"10.1523","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-357X","authenticated-orcid":false,"given":"Kevin J.","family":"Clancy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Andrzejewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhou","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman B.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-6135","authenticated-orcid":false,"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"2023041302145666000_7.4.ENEURO.0053-20.2020.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.04.046"},{"key":"2023041302145666000_7.4.ENEURO.0053-20.2020.2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0840-4"},{"key":"2023041302145666000_7.4.ENEURO.0053-20.2020.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.005"},{"key":"2023041302145666000_7.4.ENEURO.0053-20.2020.4","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, Ed 5. 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