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Older lesion studies and more recent electrophysiological studies have, however, indicated that it is involved in temporal perception and temporal expectation building. An outstanding question is whether this temporal expectation building cerebellar activity has functional relevance. In this study, we collected magnetoencephalographic data from 30 healthy participants performing a detection task on at-threshold stimulation that was presented at the end of a sequence of temporally regular or irregular above-threshold stimulation. We found that behavioral detection rates depended on the degree of irregularity in the sequence preceding it. We also found cerebellar responses evoked by above-threshold and at-threshold stimulation. The evoked responses to at-threshold stimulation differed significantly, depending on whether it was preceded by a regular or an irregular sequence. Finally, we found that detection performance across participants correlated significantly with the differences in cerebellar evoked responses to the at-threshold stimulation, demonstrating the functional relevance of cerebellar activity in sensory expectation building. We furthermore found evidence of thalamic involvement, as indicated by responses in the beta band (14\u201330\u2005Hz) and by significant modulations of cerebello-thalamic connectivity by the regularity of the sequence and the kind of stimulation terminating the sequence. These results provide evidence that the temporal expectation building mechanism of the cerebellum, what we and others have called an internal clock, shows functional relevance by regulating behavior and performance in sensory action that requires acting and integrating evidence over precise timescales.<\/jats:p>","DOI":"10.1523\/eneuro.0070-24.2024","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T13:50:20Z","timestamp":1712238620000},"page":"ENEURO.0070-24.2024","source":"Crossref","is-referenced-by-count":11,"title":["Detection of Threshold-Level Stimuli Modulated by Temporal Predictions of the Cerebellum"],"prefix":"10.1523","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-0614","authenticated-orcid":false,"given":"Lau M.","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarang S.","family":"Dalal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118202"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119238"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116817"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.014"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.irbm.2009.01.005"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.6","doi-asserted-by":"publisher","DOI":"10.1515\/rns.2011.056"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059856"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.8","doi-asserted-by":"crossref","unstructured":"Bates D , M\u00e4chler M , Bolker B , Walker S (2014) Fitting linear mixed-effects models using lme4. arXiv:14065823 [stat] Available at: http:\/\/arxiv.org\/abs\/1406.5823 [Accessed August 25, 2021].","DOI":"10.18637\/jss.v067.i01"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.9","doi-asserted-by":"publisher","DOI":"10.1162\/neco.2007.19.2.442"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.03.003"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.11","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-010-9143-9"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.12","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb1141"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.13","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200108080-00039"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2021.02.019"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.15","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"2024042910551706000_11.4.ENEURO.0070-24.2024.16","doi-asserted-by":"crossref","unstructured":"D\u2019Angelo E (2018) Chapter 6: Physiology of the cerebellum. 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