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To address RNF216 action in cognitive and motor functions, we tested<jats:italic>Rnf216<\/jats:italic>knock-out (KO) mice in a battery of motor and learning tasks for a duration of 1\u2005year. Although male and female KO mice did not demonstrate prominent motor phenotypes, KO females displayed abnormal limb clasping. KO mice also showed age-dependent strategy and associative learning impairments with sex-dependent alterations of microglia in the hippocampus and cortex. Additionally, KO males but not females had more negative resting membrane potentials in the CA1 hippocampus without any changes in miniature excitatory postsynaptic current (mEPSC) frequencies or amplitudes. Our findings show that constitutive deletion of<jats:italic>Rnf216<\/jats:italic>alters microglia and neuronal excitability, which may provide insights into the etiology of sex-specific impairments in GHS.<\/jats:p>","DOI":"10.1523\/eneuro.0074-23.2023","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T18:50:15Z","timestamp":1703703015000},"page":"ENEURO.0074-23.2023","source":"Crossref","is-referenced-by-count":4,"title":["Gordon Holmes Syndrome Model Mice Exhibit Alterations in Microglia, Age, and Sex-Specific Disruptions in Cognitive and Proprioceptive Function"],"prefix":"10.1523","volume":"11","author":[{"given":"Arlene J.","family":"George","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanya 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