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Expression of pain by one individual can be communicated to nearby individuals by auditory, visual, and olfactory cues. Conversely, the perception of another\u2019s pain can lead to physiological and behavioral changes in the observer, which can include induction of hyperalgesia in \u201cbystanders\u201d exposed to \u201cprimary\u201d conspecifics in which hyperalgesia has been induced directly. The current studies were designed to investigate the neural mechanisms responsible for the social transfer of hyperalgesia in bystander mice housed and tested with primary mice in which hyperalgesia was induced using withdrawal (WD) from voluntary alcohol consumption. Male C57BL\/6J mice undergoing WD from a two-bottle choice voluntary alcohol-drinking procedure served as the primary mice. Mice housed in the same room served as bystanders. Na\u00efve, water-drinking controls were housed in a separate room. Immunohistochemical mapping identified significantly enhanced Fos immunoreactivity (Fos-ir) in the anterior cingulate cortex (ACC) and insula (INS) of bystander mice compared to na\u00efve controls, and in the dorsal medial hypothalamus (DMH) of primary mice. Chemogenetic inactivation of the ACC but not primary somatosensory cortex reversed the expression of hyperalgesia in both primary and bystander mice. These studies point to an overlapping neural substrate for expression of socially transferred hyperalgesia and that expressed during alcohol WD.<\/jats:p>","DOI":"10.1523\/eneuro.0087-17.2017","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T12:53:50Z","timestamp":1501073630000},"page":"ENEURO.0087-17.2017","source":"Crossref","is-referenced-by-count":42,"title":["Anterior Cingulate Cortex Contributes to Alcohol Withdrawal- Induced and Socially Transferred Hyperalgesia"],"prefix":"10.1523","volume":"4","author":[{"given":"Monique L.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre. 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