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Lesions of the dorsolateral frontal cortex that include area 8A in the human brain and lesions restricted to area 8A in the macaque monkey have demonstrated impairments in tasks requiring selection between visual targets based on rules, such as conditional if\/then rules. These same subjects show no impairment in the ability to discriminate between visual stimuli nor in the ability to learn selection rules in general. Area 8A can be considered as a key area for the top-down control of attentional selection. The present functional neuroimaging study demonstrates that activity in area 8A that lies on the posterior part of the middle frontal gyrus underlies the trial-to-trial selection between competing visual targets based on previously acquired conditional rules. Critically, the activity of area 8A could clearly be dissociated from activity related to the performance of eye movements per se that lies posterior to it. Thus, area 8A with its rich corticocortical connections with the posterior parietal region involved in spatial processing and the multisensory temporal cortex appears to be the key prefrontal area for the higher order selection between competing stimuli in the environment, most likely by the allocation of attention.<\/jats:p>","DOI":"10.1523\/eneuro.0102-20.2020","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T21:52:17Z","timestamp":1597701137000},"page":"ENEURO.0102-20.2020","source":"Crossref","is-referenced-by-count":25,"title":["Area 8A within the Posterior Middle Frontal Gyrus Underlies Cognitive Selection between Competing Visual Targets"],"prefix":"10.1523","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-8226","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Germann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Petrides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"2023041302150670000_7.5.ENEURO.0102-20.2020.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.07.010"},{"key":"2023041302150670000_7.5.ENEURO.0102-20.2020.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1567-z"},{"key":"2023041302150670000_7.5.ENEURO.0102-20.2020.3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4739-05.2006"},{"key":"2023041302150670000_7.5.ENEURO.0102-20.2020.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247003"},{"key":"2023041302150670000_7.5.ENEURO.0102-20.2020.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.05.001"},{"key":"2023041302150670000_7.5.ENEURO.0102-20.2020.6","doi-asserted-by":"crossref","unstructured":"Brass M , Derrfuss J , von Cramon Y (2008) The role of the posterior frontolateral cortex in task related control. 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