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However, based either on \u201cfear of movement\/(re)injury\/kinesiophobia,\u201d \u201cfear avoidance beliefs,\u201d or \u201cpain anxiety,\u201d pain-related fear constructs plausibly differ while it is unclear how specific the questionnaires are in assessing these different constructs. Furthermore, the relationship of pain-related fear to other anxiety measures such as state or trait anxiety remains ambiguous. Advances in neuroimaging such as machine learning on brain activity patterns recorded by functional magnetic resonance imaging might help to dissect commonalities or differences across pain-related fear constructs. We applied a pattern regression approach in 20 human patients with nonspecific chronic low back pain to reveal predictive relationships between fear-related neural pattern information and different pain-related fear questionnaires. More specifically, the applied multiple kernel learning approach allowed the generation of models to predict the questionnaire scores based on a hierarchical ranking of fear-related neural patterns induced by viewing videos of activities potentially harmful for the back. We sought to find evidence for or against overlapping pain-related fear constructs by comparing the questionnaire prediction models according to their predictive abilities and associated neural contributors. By demonstrating evidence of nonoverlapping neural predictors within fear-processing regions, the results underpin the diversity of pain-related fear constructs. This neuroscientific approach might ultimately help to further understand and dissect psychological pain-related fear constructs.<\/jats:p>","DOI":"10.1523\/eneuro.0107-18.2018","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T18:09:10Z","timestamp":1545847750000},"page":"ENEURO.0107-18.2018","source":"Crossref","is-referenced-by-count":16,"title":["Pain-Related Fear\u2014Dissociable Neural Sources of Different Fear Constructs"],"prefix":"10.1523","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6004-8338","authenticated-orcid":false,"given":"Michael Lukas","family":"Meier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vrana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry Kim","family":"Humphreys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Seifritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-2416","authenticated-orcid":false,"given":"Philipp","family":"St\u00e4mpfli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Schweinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2018,12,26]]},"reference":[{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7549.1080"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.2","doi-asserted-by":"publisher","DOI":"10.1162\/08989290260138618"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.3","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-015-0339-6"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2016.05.005"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.7","doi-asserted-by":"publisher","DOI":"10.1037\/a0039449"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0908-17.2017"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2017.09.012"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.10","first-page":"A13","article-title":"A catalog of biases in questionnaires","volume":"2","year":"2005","journal-title":"Prev Chronic Dis"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.11","doi-asserted-by":"publisher","DOI":"10.1027\/1614-0001.28.4.179"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.12","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00229-2"},{"key":"2023041302131544000_5.6.ENEURO.0107-18.2018.14","doi-asserted-by":"crossref","unstructured":"Darwin C (1873) The expression of the emotions in man and animals. 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