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The conflicting literature in rodent models may be at least partly because of the use of drug exposure paradigms that do not closely mirror patterns of human<jats:italic>Cannabis<\/jats:italic>use. Here, we used an incidental memory capacity paradigm where a novelty preference is assessed after a short delay in spontaneous recognition-based tests. Either object or odor-based stimuli were used in test variations with sets of identical [identical stimuli test (IST)] and different [different stimuli test (DST)] stimuli (three or six) for low-memory and high-memory loads, respectively. Additionally, we developed a human-machine hybrid behavioral quantification approach which supplements stopwatch-based scoring with supervised machine learning-based classification. After validating the spontaneous IST and DST in male rats, 6-item test versions with the hybrid quantification method were used to evaluate the impact of acute exposure to high-\u0394<jats:sup>9<\/jats:sup>-tetrahydrocannabinol (THC) or high-CBD<jats:italic>Cannabis<\/jats:italic>smoke on novelty preference. Under control conditions, male rats showed novelty preference in all test variations. We found that high-THC, but not high-CBD,<jats:italic>Cannabis<\/jats:italic>smoke exposure impaired novelty preference for objects under a high-memory load. Odor-based recognition deficits were seen under both low-memory and high-memory loads only following high-THC smoke exposure. Ultimately, these data show that<jats:italic>Cannabis<\/jats:italic>smoke exposure impacts incidental memory capacity of male rats in a memory load-dependent, and stimuli-specific manner.<\/jats:p>","DOI":"10.1523\/eneuro.0115-23.2023","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T18:50:23Z","timestamp":1700160623000},"page":"ENEURO.0115-23.2023","source":"Crossref","is-referenced-by-count":9,"title":["High-THC<i>Cannabis<\/i>Smoke Impairs Incidental Memory Capacity in Spontaneous Tests of Novelty Preference for Objects and Odors in Male Rats"],"prefix":"10.1523","volume":"10","author":[{"given":"Ilne L.","family":"Barnard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Onofrychuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron 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