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However, there is evidence for abnormal connectivity outside the SOZ (NSOZ), and removal of the SOZ does not always result in seizure control, suggesting, in some cases, that the extent of abnormal connectivity indicates a larger seizure network than the SOZ. To better understand the potential differences in interictal functional connectivity in relation to the seizure network and outcome, we computed event connectivity in the theta (4\u20138 Hz, ThEC), low-gamma (30\u201355 Hz, LGEC), and high-gamma (65\u201395 Hz, HGEC) bands from interictal depth EEG recorded in surgical patients with medication-resistant seizures suspected to begin in the temporal lobe. Analysis finds stronger LGEC and HGEC in SOZ than NSOZ of seizure-free (SF) patients (<jats:italic>p<\/jats:italic>\u2009=\u20091.10e-9, 0.0217), but no difference in not seizure-free (NSF) patients. There were stronger LGEC and HGEC between mesial and lateral temporal SOZ of SF than NSF patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.00114, 0.00205), and stronger LGEC and ThEC in NSOZ of NSF than SF patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.0089, 0.0111). These results show that event connectivity is sensitive to differences in the interactions between regions in SOZ and NSOZ and SF and NSF patients. Patients with differential strengths in event connectivity could represent a well-localized seizure network, whereas an absence of differences could indicate a larger seizure network than the one localized by the SOZ and higher likelihood for seizure recurrence.<\/jats:p>","DOI":"10.1523\/eneuro.0141-22.2022","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:58:43Z","timestamp":1669298323000},"page":"ENEURO.0141-22.2022","source":"Crossref","is-referenced-by-count":16,"title":["Interictal Gamma Event Connectivity Differentiates the Seizure Network and Outcome in Patients after Temporal Lobe Epilepsy Surgery"],"prefix":"10.1523","volume":"9","author":[{"given":"Mohamad","family":"Shamas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang J.","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itzhak","family":"Fried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2285-5627","authenticated-orcid":false,"given":"Richard","family":"Staba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(61)80002-2"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.2","doi-asserted-by":"publisher","DOI":"10.1007\/s11571-019-09553-w"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.3","doi-asserted-by":"publisher","DOI":"10.1038\/383815a0"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.4","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2013.00140"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2020.106449"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2020.03.011"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.7","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn111"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2008.02.013"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02690.x"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.06.003"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.11","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13791"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.12","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2044"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2008.04.020"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020071"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.15","first-page":"14","article-title":"iElectrodes: a comprehensive open-source toolbox for depth and subdural grid electrode localization","volume":"11","year":"2017","journal-title":"Front Neuroinformatics"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.16","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.155291"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085900"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2014.09.003"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00586-X"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150444"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.21","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2012.14.4\/gbuzsaki"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.11.033"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.019"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.24","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.618"},{"key":"2023041302171710000_9.6.ENEURO.0141-22.2022.25","unstructured":"Cohen J (1988) Statistical power analysis for the behavioral sciences, Ed 2. 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