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Approximately 70% of all drug overdose deaths are attributable to fentanyl, demonstrating a need to identify risk factors underlying the escalation of fentanyl use. Nicotine use is a risk factor associated with increased consumption of opioids across both clinical and preclinical populations. Our prior findings show that nicotine administration escalates consumption of opioids and that this elevated consumption persists despite adverse consequences in rodents, demonstrating a behavioral phenotype resembling those that emerge following protracted experience with opioids. Prolonged drug consumption is associated with a shift toward increased dopamine (DA) transmission within dorsolateral striatum (DLS), a brain area critical for the development of inflexible behaviors. The present study sought to characterize the behavioral and neurochemical effects of nicotine on fentanyl administration. A dose\u2013response curve was used to determine the effect of nicotine on fentanyl consumption as a function of dose in males and females. Systemic pretreatment with nicotine-enhanced fentanyl intake across all doses relative to nicotine-naive controls, suggesting that nicotine augments responding for opioids without evident effects on sensitivity to fentanyl. Additionally, fast-scan cyclic voltammetry was applied to measure DLS DA transmission in response to fentanyl administration and to quantify any effect of nicotine on this response in male rats. Fentanyl administration enhanced DA concentrations within DLS, and this effect was potentiated by nicotine pretreatment. These findings support that enhanced DA transmission in DLS may mechanistically contribute to nicotine-induced increases in the motivation for opioids.<\/jats:p>","DOI":"10.1523\/eneuro.0161-26.2026","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:50:14Z","timestamp":1791568214000},"page":"ENEURO.0161-26.2026","update-policy":"https:\/\/doi.org\/10.1523\/eneuro.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Nicotine Administration Robustly Enhances Fentanyl-Induced Dopamine Transmission within the Dorsolateral Striatum"],"prefix":"10.1523","volume":"13","author":[{"given":"Rohan V.","family":"Bhimani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Honeycutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Carl","family":"Loney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-1120","authenticated-orcid":false,"given":"Jinwoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"2026102910551659000_13.10.ENEURO.0161-26.2026.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1595-7"},{"key":"2026102910551659000_13.10.ENEURO.0161-26.2026.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.12.019"},{"key":"2026102910551659000_13.10.ENEURO.0161-26.2026.3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/FBP.0000000000000205","article-title":"Effects of sex and remifentanil dose on rats\u2019 acquisition of responding for a remifentanil-conditioned reinforcer","volume":"27","author":"Bertz","year":"2016","journal-title":"Behav Pharmacol"},{"key":"2026102910551659000_13.10.ENEURO.0161-26.2026.4","doi-asserted-by":"publisher","DOI":"10.1177\/1534582304272005"},{"key":"2026102910551659000_13.10.ENEURO.0161-26.2026.5","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/jnc.15470","article-title":"Distinct dose-dependent effects of methamphetamine on real-time dopamine transmission in the rat nucleus accumbens and behaviors","volume":"158","author":"Bhimani","year":"2021","journal-title":"J Neurochem"},{"key":"2026102910551659000_13.10.ENEURO.0161-26.2026.6","doi-asserted-by":"crossref","first-page":"e70516","DOI":"10.1111\/jnc.70516","article-title":"Opposing estrous cycle-dependent norepinephrine and dopamine regulation in response to methamphetamine","volume":"170","author":"Bhimani","year":"2026","journal-title":"J Neurochem"},{"key":"2026102910551659000_13.10.ENEURO.0161-26.2026.7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0924-977X(97)00052-7","article-title":"Studies on the role of nicotinic acetylcholine receptors in the discriminative and aversive stimulus properties of ethanol in the rat","volume":"8","author":"Bienkowskia","year":"1998","journal-title":"Eur Neuropsychopharmacol"},{"key":"2026102910551659000_13.10.ENEURO.0161-26.2026.8","unstructured":"Bjo\u0166rklund A , Lindvall O (1984) Dopamine-containing system in the CNS. 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