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While previous studies focusing on single tasks have demonstrated that attention shifts tuning toward attended targets, real-world behavior often requires humans to switch between tasks with different demands. How does visual-semantic tuning in the human brain shift to support the behavioral demands of different naturalistic tasks? To investigate this question, we used voxelwise encoding models to explore how visual-semantic tuning across the human cerebral cortex shifts between two naturalistic human fMRI experiments that used distinct tasks, movie-watching (five male participants) and active navigation (six participants, three male, three female). Results show that visual-semantic tuning in the cortex differed substantially between experiments. Principal component analysis reveals that during navigation, tuning shifts increase the representation of vehicles and traffic signs compared with movie-watching and that these shifts are localized to distinct functional networks. These tuning shifts reconfigure the human brain\u2019s representations of object categories based on their behavioral relevance. 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