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Here, we analyzed local field potential (LFP) activity in freely behaving, symptomatic R6\/2 and Q175 mouse models and corresponding wild-type (WT) controls. We focused on periods of quiet rest, which show strong \u03b3 activity in HD mice. Simultaneous recording from motor cortex and its target area in dorsal striatum in the R6\/2 model revealed exaggerated functional coupling over that observed in WT between the phase of delta frequencies (1\u20134 Hz) in cortex and striatum and striatal amplitude modulation of low \u03b3 frequencies (25\u201355 Hz; i.e., phase-amplitude coupling, PAC), but no evidence that abnormal cortical activity alone can account for the increase in striatal \u03b3 power. Both HD mouse models had stronger coupling of \u03b3 amplitude to \u03b4 phase and more unimodal phase distributions than their WT counterparts. To assess the possible role of striatal fast-spiking interneurons (FSIs) in these phenomena, we developed a computational model based on additional striatal recordings from Q175 mice. Changes in peak \u03b3 frequency and power ratio were readily reproduced by our computational model, accounting for several experimental findings reported in the literature. Our results suggest that HD is characterized by both a reorganization of cortico-striatal drive and specific population changes related to intrastriatal synaptic coupling.<\/jats:p>","DOI":"10.1523\/eneuro.0210-18.2018","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T23:15:13Z","timestamp":1543533313000},"page":"ENEURO.0210-18.2018","source":"Crossref","is-referenced-by-count":21,"title":["Cortico-Striatal Cross-Frequency Coupling and Gamma Genesis Disruptions in Huntington\u2019s Disease Mouse and Computational Models"],"prefix":"10.1523","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-402X","authenticated-orcid":false,"given":"Sebastien","family":"Naze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Humble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengsheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rangel-Barajas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-7796","authenticated-orcid":false,"given":"George V.","family":"Rebec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-4688","authenticated-orcid":false,"given":"James R.","family":"Kozloski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2727"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00134.x"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.3","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00046"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.02.008"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.5","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2044"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(04)74250-2"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.8","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.73.051911"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.9","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v031.i10"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06843.x"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.11","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00045"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.035"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.13","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008925309027"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.14","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00317"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150444"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.16","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3952"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.17","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3241"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2944-15.2017"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0735-13.2013"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.11.001"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2137-12.2013"},{"key":"2023041302131593000_5.6.ENEURO.0210-18.2018.22","unstructured":"Chartove JA , Pittman-Polletta BR , McCarthy MM , Kopell NJ (2017) Gamma and theta rhythms in networks of striatal fast-spiking interneurons modulate oscillatory behavior of striatal projection neurons. 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