{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:11:30Z","timestamp":1787022690917,"version":"build-2736575974"},"reference-count":65,"publisher":"Society for Neuroscience","issue":"10","content-domain":{"domain":["eneuro.org"],"crossmark-restriction":true},"short-container-title":["eNeuro"],"accepted":{"date-parts":[[2025,9,24]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Novel stimuli can be stressful for individuals with autism spectrum disorders (ASD), though repeated exposure can reduce this effect. In\n                    <jats:italic>\n                      Cntnap2\n                      <jats:sup>-\/-<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      Shank3B\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mouse models of ASD, novel background odors impaired behavioral target odor recognition but that deficit improved with training. To investigate the neural basis of this improvement, we used wide-field calcium imaging to measure olfactory bulb responses in\n                    <jats:italic>\n                      Cntnap2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      Shank3B\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice and WT mice of either sex. Training with background odors enhanced both behavioral performance and neural discriminability of odor mixtures in both\n                    <jats:italic>\n                      Cntnap2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      Shank3B\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    as well as WT mice. Naive\n                    <jats:italic>\n                      Cntnap2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      Shank3B\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice showed greater trial-to-trial neural variability than WT mice, but training stabilized neural responses. Critically, training produced a widespread reduction in olfactory bulb responses to background odors in ASD models, but not in WT mice. Thus, despite similar behavioral improvements as WT mice,\n                    <jats:italic>\n                      Cntnap2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      Shank3B\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice relied on a distinct broad suppression of background odor responses to enhance olfactory coding in the presence of background odors.\n                  <\/jats:p>","DOI":"10.1523\/eneuro.0271-25.2025","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:50:24Z","timestamp":1759945824000},"page":"ENEURO.0271-25.2025","update-policy":"https:\/\/doi.org\/10.1523\/eneuro.crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Odor Experience Stabilizes Glomerular Output Representations in Two Mouse Models of Autism"],"prefix":"10.1523","volume":"12","author":[{"given":"Kassandra L.","family":"Sturm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryna","family":"Semak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe A.","family":"Scheier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raddy L.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo H.","family":"Otazu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.1","doi-asserted-by":"crossref","first-page":"e76882","DOI":"10.7554\/eLife.76882","article-title":"State-dependent representations of mixtures by the olfactory bulb","volume":"11","author":"Adefuin","year":"2022","journal-title":"Elife"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.2","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2018.12.026"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0355-19.2019"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.4","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.1.489"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.02.013"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43777-z"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat6904"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.020"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.047"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80647-9"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-05-02011.2000"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.09.005"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0598-6"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108697"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.15","unstructured":"Ernsperger L , Stegen-Hanson T (2004) Just take a bite: easy, effective answers to food aversions and eating challenges . Future Horizons, Inc."},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.16","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2258"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.017"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.18","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3760"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.19","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00277.2019"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2368-09.2009"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0445-9"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2563-7"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.23","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-019-0257-5"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0154-12.2012"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.09.037"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.26","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_5003"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.27","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0584-23.2023"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.28","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41467-023-36346-x","article-title":"Robust odor identification in novel olfactory environments in mice","volume":"14","author":"Li","year":"2023","journal-title":"Nat Commun"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002536"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.30","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1177\/1362361318815252","article-title":"Effects of familiarization on odor hedonic responses and food choices in children with autism spectrum disorders","volume":"23","author":"Luisier","year":"2019","journal-title":"Autism"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.028"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.32","doi-asserted-by":"publisher","DOI":"10.1152\/jn.91019.2008"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.rasd.2019.04.002","article-title":"Atypical eating behaviors in children and adolescents with autism, ADHD, other disorders, and typical development","volume":"64","author":"Mayes","year":"2019","journal-title":"Res Autism Spectr Disord"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.34","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjt018"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.35","first-page":"541926","article-title":"Association of sensory processing and eating problems in children with autism spectrum disorders","volume":"2011","author":"Nadon","year":"2011","journal-title":"Autism Res Treat"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fncir.2010.00120","article-title":"Differential axonal projection of mitral and tufted cells in the mouse main olfactory system","volume":"4","author":"Nagayama","year":"2010","journal-title":"Front Neural Circuits"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.03.033"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.024"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26402-9"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.05.023"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.41","doi-asserted-by":"publisher","DOI":"10.1038\/nature09965"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.040"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.43","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010257"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.44","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2335"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.45","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305018"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.isci.2019.06.014","article-title":"Chemogenetic activation of prefrontal cortex in Shank3-deficient mice ameliorates social deficits, NMDAR hypofunction, and Sgk2 downregulation","volume":"17","author":"Qin","year":"2019","journal-title":"IScience"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.47","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3775"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.48","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-021-04904-1"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.05.048"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.50","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-183X.2003.00037.x"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.51","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0255-23.2023"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18861-3"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.53","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.70008"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.54","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22489"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.55","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00389-0"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.56","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1093\/cercor\/bhab517","article-title":"Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked CNTNAP2 gene","volume":"32","author":"Scott","year":"2022","journal-title":"Cereb Cortex"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.57","doi-asserted-by":"publisher","DOI":"10.1093\/CERCOR\/BHX341"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.58","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah6733"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-016-0009-6"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10578-019-00923-3","article-title":"A pilot study of family-based exposure-focused treatment for youth with autism spectrum disorder and anxiety","volume":"51","author":"Storch","year":"2020","journal-title":"Child Psychiatry Hum Develop"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.61","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90569-X"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.62","doi-asserted-by":"publisher","DOI":"10.1038\/nn1892"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.63","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0416-4"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.64","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjn029"},{"key":"2025102910501597000_12.10.ENEURO.0271-25.2025.65","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13229-016-0070-3","article-title":"Olfactory processing in adults with autism spectrum disorders","volume":"7","author":"Wicker","year":"2016","journal-title":"Mol Autism"}],"container-title":["eneuro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0271-25.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:50:34Z","timestamp":1761760234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eneuro.org\/lookup\/doi\/10.1523\/ENEURO.0271-25.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":65,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,29]]},"published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1523\/ENEURO.0271-25.2025"],"URL":"https:\/\/doi.org\/10.1523\/eneuro.0271-25.2025","relation":{},"ISSN":["2373-2822"],"issn-type":[{"value":"2373-2822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}