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Using multisite silicon probe recordings of epileptic rats engaged in episodic-like object recognition tasks, we sought to evaluate the role of theta\u2013gamma coupling in the absence of epileptiform activities. Our data reveal a specific association between theta\u2013gamma (30\u201360 Hz) coupling at the proximal stratum radiatum of CA1 and spatial memory deficits. We targeted the microcircuit mechanisms with a novel approach to identify putative interneuronal types in tetrode recordings (parvalbumin basket cells in particular) and validated classification criteria in the epileptic context with neurochemical identification of intracellularly recorded cells. In epileptic rats, putative parvalbumin basket cells fired poorly modulated at the falling theta phase, consistent with weaker inputs from Schaffer collaterals and attenuated gamma oscillations, as evaluated by theta-phase decomposition of current\u2013source density signals. We propose that theta\u2013gamma interneuronal rhythmopathies of the temporal lobe are intimately related to episodic memory dysfunction in this condition.<\/jats:p>","DOI":"10.1523\/eneuro.0284-16.2016","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T02:34:05Z","timestamp":1478572445000},"page":"ENEURO.0284-16.2016","source":"Crossref","is-referenced-by-count":60,"title":["Altered Oscillatory Dynamics of CA1 Parvalbumin Basket Cells during Theta\u2013Gamma Rhythmopathies of Temporal Lobe Epilepsy"],"prefix":"10.1523","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6178-5951","authenticated-orcid":false,"given":"Diego","family":"Lopez-Pigozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge 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