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Empirical evidence notwithstanding, there is still no universal understanding of KD mechanism(s). An important fact is that the brain is capable of using ketone bodies for fuel. Another critical point is that glucose\u2019s functions span beyond its role as an energy substrate, and in most of these functions, glucose is irreplaceable. By acting as a supplementary fuel, ketone bodies may free up glucose for its other crucial and exclusive function. We propose that this glucose-sparing effect of ketone bodies may underlie the effectiveness of KD in epilepsy and major neurodegenerative diseases, which are all characterized by brain glucose hypometabolism.<\/jats:p>","DOI":"10.1523\/eneuro.0303-20.2020","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T18:25:14Z","timestamp":1604946314000},"page":"ENEURO.0303-20.2020","source":"Crossref","is-referenced-by-count":23,"title":["Glucose-Sparing Action of Ketones Boosts Functions Exclusive to Glucose in the Brain"],"prefix":"10.1523","volume":"7","author":[{"given":"Yuri","family":"Zilberter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Zilberter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"2023041302152004000_7.6.ENEURO.0303-20.2020.1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.45.12.2261"},{"key":"2023041302152004000_7.6.ENEURO.0303-20.2020.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1996.tb00022.x"},{"key":"2023041302152004000_7.6.ENEURO.0303-20.2020.3","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12964"},{"key":"2023041302152004000_7.6.ENEURO.0303-20.2020.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.03.007"},{"key":"2023041302152004000_7.6.ENEURO.0303-20.2020.5","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101695"},{"key":"2023041302152004000_7.6.ENEURO.0303-20.2020.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600281"},{"key":"2023041302152004000_7.6.ENEURO.0303-20.2020.7","doi-asserted-by":"crossref","unstructured":"Barros LF , Felipe Barros L , Ruminot I , Mart\u00edn AS , Lerchundi R , Fern\u00e1ndez-Moncada I , Baeza-Lehnert F (2020) Aerobic glycolysis in the brain: Warburg and Crabtree contra Pasteur. 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