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Patients were implanted with chronic bilateral deep brain stimulation (DBS) leads in the subthalamic nucleus (STN) and electrocorticography paddles overlaying the primary motor and somatosensory cortices. Local field potentials were recorded from these areas while the participants performed overground walking and synchronized to external gait kinematic sensors. We found that the STN displays increased low-frequency (4\u201312\u2009Hz) spectral power during the period before contralateral leg swing. Furthermore, STN shows increased theta frequency (4\u20138\u2009Hz) coherence with the primary motor through the initiation and early phase of contralateral leg swing. Additional analysis revealed that each patient had specific frequency bands that could detect a significant difference between left and right initial leg swing. Our findings indicate that there are alternating spectral changes between the two hemispheres in accordance with the gait cycle. In addition, we identified patient-specific, gait-related biomarkers in both the STN and cortical areas at discrete frequency bands that may be used to drive adaptive DBS to improve gait dysfunction in patients with Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1523\/eneuro.0325-22.2022","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T12:26:56Z","timestamp":1667219216000},"page":"ENEURO.0325-22.2022","source":"Crossref","is-referenced-by-count":32,"title":["Cortico-Subthalamic Field Potentials Support Classification of the Natural Gait Cycle in Parkinson\u2019s Disease and Reveal Individualized Spectral Signatures"],"prefix":"10.1523","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-1521","authenticated-orcid":false,"given":"Kenneth 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