{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:27:43Z","timestamp":1778858863373,"version":"3.51.4"},"reference-count":62,"publisher":"Society for Neuroscience","issue":"2","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Netherlands Organisation for Scientific Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["eNeuro"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dopamine has been associated with risky decision-making, as well as with pathological gambling, a behavioral addiction characterized by excessive risk-taking behavior. However, the specific mechanisms through which dopamine might act to foster risk-taking and pathological gambling remain elusive. Here we test the hypothesis that this might be achieved, in part, via modulation of subjective probability weighting during decision making. Human healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    = 21) and pathological gamblers (\n                    <jats:italic>n<\/jats:italic>\n                    = 16) played a decision-making task involving choices between sure monetary options and risky gambles both in the gain and loss domains. Each participant played the task twice, either under placebo or the dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    \/D\n                    <jats:sub>3<\/jats:sub>\n                    receptor antagonist sulpiride, in a double-blind counterbalanced design. A prospect theory modelling approach was used to estimate subjective probability weighting and sensitivity to monetary outcomes. Consistent with prospect theory, we found that participants presented a distortion in the subjective weighting of probabilities, i.e., they overweighted low probabilities and underweighted moderate to high probabilities, both in the gain and loss domains. Compared with placebo, sulpiride attenuated this distortion in the gain domain. Across drugs, the groups did not differ in their probability weighting, although gamblers consistently underweighted losing probabilities in the placebo condition. Overall, our results reveal that dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    \/D\n                    <jats:sub>3<\/jats:sub>\n                    receptor antagonism modulates the subjective weighting of probabilities in the gain domain, in the direction of more objective, economically rational decision making.\n                  <\/jats:p>","DOI":"10.1523\/eneuro.0330-18.2018","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T14:15:44Z","timestamp":1521209744000},"page":"ENEURO.0330-18.2018","source":"Crossref","is-referenced-by-count":21,"title":["Dopaminergic Drug Effects on Probability Weighting during Risky Decision Making"],"prefix":"10.1523","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9138-9733","authenticated-orcid":false,"given":"Karita E.","family":"Ojala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0166-8163","authenticated-orcid":false,"given":"Lieneke K.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-2816","authenticated-orcid":false,"given":"Mahur M.","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique H. M.","family":"Timmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-1301","authenticated-orcid":false,"given":"Dirk E. M.","family":"Geurts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels P.","family":"ter Huurne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8994-5534","authenticated-orcid":false,"given":"Roshan","family":"Cools","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-3755","authenticated-orcid":false,"given":"Guillaume","family":"Sescousse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.1","doi-asserted-by":"publisher","DOI":"10.1007\/s11166-008-9039-8"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.2","doi-asserted-by":"publisher","DOI":"10.1287\/mnsc.1110.1324"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.3","unstructured":"American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR (4th ed., text rev.). Washington, DC: Author."},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2225-15.2016"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.5","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.163"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.6","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00357"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.7","doi-asserted-by":"crossref","unstructured":"Burke CJ , Soutschek A , Weber S , Beharelle AR , Fehr E , Haker H , Tobler PN (2017) Dopamine receptor-specific contributions to the computation of value. Neuropsychopharmacology, in press.","DOI":"10.1038\/npp.2017.302"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0626-12.2012"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.9","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23247"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.10","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.84"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.11","doi-asserted-by":"publisher","DOI":"10.1007\/s11238-005-4590-0"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.12","doi-asserted-by":"crossref","unstructured":"Fox CR , Poldrack RA (2014) Appendix: prospect theory and the brain. In: Neuroeconomics: decision making and the brain ( Glimcher PW , Camerer CF , Fehr E , Poldrack RA , eds), pp 533\u2013567. New York: Academic Press.","DOI":"10.1016\/B978-0-12-416008-8.00042-5"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.13","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102941"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.14","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.120.3.497"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.15","doi-asserted-by":"publisher","DOI":"10.1006\/cogp.1998.0710"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.16","doi-asserted-by":"crossref","unstructured":"Grissom RJ , Kim JJ (2012) Effect sizes for research: univariate and multivariate applications. Routledge: New York, NY.","DOI":"10.4324\/9780203803233"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.18","doi-asserted-by":"crossref","unstructured":"Heathcote A , Brown SD , Wagenmakers E-J (2015) An introduction to good practices in cognitive modeling. In: An introduction to model-based cognitive neuroscience ( Forstmann BU , Wagenmakers E-J , eds), pp 25\u201348. New York: Springer New York.","DOI":"10.1007\/978-1-4939-2236-9_2"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2009.09.004"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5296-08.2009"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.21","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-3986-y"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3904-10.2011"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.23","doi-asserted-by":"publisher","DOI":"10.2307\/1914185"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.24","doi-asserted-by":"publisher","DOI":"10.1024\/0939-5911\/a000430"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-2681(95)90015-2"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.26","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.9.1184"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.27","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001900"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.28","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.113"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03300.x"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039135"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.31","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-12.2013"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.08.012"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-017-0219-x"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.34","doi-asserted-by":"publisher","DOI":"10.1038\/nature05051"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.35","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.167"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.36","doi-asserted-by":"publisher","DOI":"10.2307\/2998573"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.37","doi-asserted-by":"publisher","DOI":"10.1287\/mnsc.37.7.770"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002479"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.39","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.68"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0702-15.2015"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1993.tb02093.x"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.10.002"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.43"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.44","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.43"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.45","first-page":"22","article-title":"Diagnostic Psychiatric Interview for DSM-IV and ICD-10","volume":"59","year":"1998","journal-title":"Journal of Clinical Psychiatry"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.46","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.121"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.47","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1883-y"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.48","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.240"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.49","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3933-10.2010"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.50","first-page":"11","article-title":"Mechanisms underlying dopamine-induced risky choice in Parkinson\u2019s disease with and without depression (history)","volume":"2","year":"2017","journal-title":"Comput Psych"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.51","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs344"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.52","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.170"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.53","doi-asserted-by":"crossref","unstructured":"van Holst RJ , Sescousse G , Janssen LK , Janssen M , Berry AS , Jagust WJ , Cools R (2017) Increased striatal dopamine synthesis capacity in gambling addiction. Biol Psychiatry, in press.","DOI":"10.1016\/j.biopsych.2017.06.010"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.54","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244242"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.55","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70287-X"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.56","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr080"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.obhdp.2005.03.001"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.58","unstructured":"Wuensch K (2015) CL: The Common Language Effect Size Statistic. Retrieved from http:\/\/core.ecu.edu\/psyc\/wuenschk\/docs30\/CL.pdf on the 6th of July, 2017."},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.59","doi-asserted-by":"publisher","DOI":"10.1038\/nature17400"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.60","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.62"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.61","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2009.1312"},{"key":"2023041302124106000_5.2.ENEURO.0330-18.2018.62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"}],"container-title":["eneuro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0330-18.2018","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0330-18.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T05:34:36Z","timestamp":1681364076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eneuro.org\/lookup\/doi\/10.1523\/ENEURO.0330-18.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,5,15]]},"published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1523\/ENEURO.0330-18.2018"],"URL":"https:\/\/doi.org\/10.1523\/eneuro.0330-18.2018","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/171587","asserted-by":"object"}]},"ISSN":["2373-2822"],"issn-type":[{"value":"2373-2822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}