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Cort feeds back through glucocorticoid receptors (GRs). Here we show in male Wistar rats that PVN neurons projecting to the adrenal gland do not express GRs, leaving the question of how the ANS in the PVN gets information about circulating Cort levels to control the adrenal. Since the arcuate nucleus (ARC) shows a less restrictive blood\u2013brain barrier, expresses GRs, and projects to the PVN, we investigated whether the ARC can detect and produce fast adjustments of circulating Cort. In low Cort conditions (morning), local microdialysis in the ARC with type I GR antagonist produced a fast and sustained increase of Cort. This was not observed with a type II antagonist. At the circadian peak levels of Cort (afternoon), a type II GR antagonist, but not a type I antagonist, increased Cort levels but not ACTH levels. Antagonist infusions in the PVN did not modify circulating Cort levels, demonstrating the specificity of the ARC to give Cort negative feedback. Furthermore, type I and II GR agonists in the ARC prevented the increase of Cort after stress, demonstrating the role of the ARC as sensor to modulate Cort release. Our findings show that the ARC may be essential to sense blood levels of Cort and adapt Cort secretion depending on such conditions as stress or time of day.<\/jats:p>","DOI":"10.1523\/eneuro.0350-16.2017","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T01:10:12Z","timestamp":1487121012000},"page":"ENEURO.0350-16.2017","source":"Crossref","is-referenced-by-count":31,"title":["The Arcuate Nucleus: A Site of Fast Negative Feedback for Corticosterone Secretion in Male Rats"],"prefix":"10.1523","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-7968","authenticated-orcid":false,"given":"Luis","family":"Leon-Mercado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8406-1377","authenticated-orcid":false,"given":"Daniela","family":"Herrera Moro 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