{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:14:05Z","timestamp":1792653245982,"version":"4.5.0"},"reference-count":108,"publisher":"Society for Neuroscience","issue":"3","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["100000062"],"award-info":[{"award-number":["100000062"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["R01DK099196"],"award-info":[{"award-number":["R01DK099196"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["100000062"],"award-info":[{"award-number":["100000062"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["R01DK084060"],"award-info":[{"award-number":["R01DK084060"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["100000062"],"award-info":[{"award-number":["100000062"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["P30-DK079307"],"award-info":[{"award-number":["P30-DK079307"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["eNeuro"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interstitial cystitis\/bladder pain syndrome (IC\/BPS) is a chronic voiding disorder that presents with pain in the urinary bladder and surrounding pelvic region. A growing body of evidence suggests that an increase in the permeability of the urothelium, the epithelial barrier that lines the interior of the bladder, contributes to the symptoms of IC\/BPS. To examine the consequence of increased urothelial permeability on pelvic pain and afferent excitability, we overexpressed in the urothelium claudin 2 (Cldn2), a tight junction (TJ)-associated protein whose message is significantly upregulated in biopsies of IC\/BPS patients. Consistent with the presence of bladder-derived pain, rats overexpressing Cldn2 showed hypersensitivity to von Frey filaments applied to the pelvic region. Overexpression of Cldn2 increased the expression of c-Fos and promoted the activation of ERK1\/2 in spinal cord segments receiving bladder input, which we conceive is the result of noxious stimulation of afferent pathways. To determine whether the mechanical allodynia observed in rats with reduced urothelial barrier function results from altered afferent activity, we examined the firing of acutely isolated bladder sensory neurons. In patch-clamp recordings, about 30% of the bladder sensory neurons from rats transduced with Cldn2, but not controls transduced with GFP, displayed spontaneous activity. Furthermore, bladder sensory neurons with tetrodotoxin-sensitive (TTX-S) action potentials from rats transduced with Cldn2 showed hyperexcitability in response to suprathreshold electrical stimulation. These findings suggest that as a result of a leaky urothelium, the diffusion of urinary solutes through the urothelial barrier sensitizes bladders afferents, promoting voiding at low filling volumes and pain.<\/jats:p>","DOI":"10.1523\/eneuro.0381-16.2017","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T20:10:18Z","timestamp":1494879018000},"page":"ENEURO.0381-16.2017","source":"Crossref","is-referenced-by-count":37,"title":["Urothelial Tight Junction Barrier Dysfunction Sensitizes Bladder Afferents"],"prefix":"10.1523","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-9540","authenticated-orcid":false,"given":"Nicolas","family":"Montalbetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C.","family":"Rued","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie N.","family":"Taiclet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Birder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Aura","family":"Kullmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1901-1618","authenticated-orcid":false,"given":"Marcelo D.","family":"Carattino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80332-X"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2007"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.3","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90264.2008"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00657509"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580280"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.6","first-page":"G329","article-title":"Cold-restraint stress increases rat fecal pellet output and colonic transit","volume":"258","year":"1990","journal-title":"The Am J Physiol"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0895-15.2016"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2428-10.2010"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.9","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00202.2014"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2013.12.005"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.11","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1523\/JNEUROSCI.12-12-04878.1992","article-title":"Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat","volume":"12","year":"1992","journal-title":"J Neurosci"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.12","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000137953.49304.6c"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.13","doi-asserted-by":"publisher","DOI":"10.2337\/diab.34.11.1210"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.14","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2000000500015"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.15","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00282.2013"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.16","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0057"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.17","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.18","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1523\/JNEUROSCI.23-04-01169.2003","article-title":"Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.07.044"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.20","doi-asserted-by":"publisher","DOI":"10.2174\/157015907782793630"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.21","doi-asserted-by":"publisher","DOI":"10.3109\/08990229409028876"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013934"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.23","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1523\/JNEUROSCI.22-17-07737.2002","article-title":"Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization","volume":"22","year":"2002","journal-title":"J Neurosci"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.24","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e3283476ea2"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5239-04.2005"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.26","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00945.2012"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.27","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00211.2007"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.28","doi-asserted-by":"crossref","unstructured":"de Groat WC , Yoshimura N (2009) Afferent nerve regulation of bladder function in health and disease. Handb Exp Pharmacol 91-138.","DOI":"10.1007\/978-3-540-79090-7_4"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.29","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12014"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.03.014"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.31","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3388-05.2006"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.33","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)02993-4"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.34","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.1976.sp011476","article-title":"Mechanosensitive afferent units in the hypogastric nerve of the cat","volume":"259","year":"1976","journal-title":"J Physiol"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.35","first-page":"307","article-title":"Use of vanilloids in urologic disorders","volume":"68","year":"2014","journal-title":"Prog Drug Res"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.36","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2401"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.37","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006903507321"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.38","doi-asserted-by":"publisher","DOI":"10.2174\/1876386300902010011"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.39","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00866.2003"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00030.2014"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.41","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-006-0051-8"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082591"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.43","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019604"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.064"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.09.022"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.090"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.91054.2008"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.48","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1959.sp006278"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.49","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02723-0"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.50","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)62758-2"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.51","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0360"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.52","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1523\/JNEUROSCI.22-02-00478.2002","article-title":"ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity","volume":"22","year":"2002","journal-title":"J Neurosci"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.53","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5241.1491"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.54","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00327.2009"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805636105"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.56","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00590.x"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.11.099"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.58","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.741616"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2012.03.010"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.60","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.7.1167"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.08.019"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.01.076"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.63","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02451-3"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.64","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(92)90031-B"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.65","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32816aa392"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.66","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00383.2002"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.67","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00198-6"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.09.077"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2013.12.005"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.70","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00200.2015"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.71","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02000309"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.72","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.217"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.73","first-page":"112","article-title":"Interstitial cystitis: characterization and management of an enigmatic urologic syndrome","volume":"4","year":"2002","journal-title":"Rev Urol"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.04.036"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.75","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2015.1105216"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0215r.x"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.03.084"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09843.x"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.79","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0022-5347(17)38437-9","article-title":"Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis)","volume":"145","year":"1991","journal-title":"J Urol"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.80","doi-asserted-by":"publisher","DOI":"10.1139\/y92-172"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.81","doi-asserted-by":"crossref","first-page":"10084","DOI":"10.1523\/JNEUROSCI.23-31-10084.2003","article-title":"Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.82","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000145591.35569.9e"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.83","doi-asserted-by":"publisher","DOI":"10.3791\/51413"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.84","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090552"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04062.x"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.86","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1152\/jn.1994.72.5.2420","article-title":"Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat","volume":"72","year":"1994","journal-title":"J Neurophysiol"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.87","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296826"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.88","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000118938.09119.a5"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.89","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-008-9100-8"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.90","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00216-2"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.91","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00054.x"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.92","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1242\/jeb.95.1.93","article-title":"K+ changes in the extracellular space of the spinal cord and their physiological role","volume":"95","year":"1981","journal-title":"J Exp Biol"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.93","doi-asserted-by":"crossref","first-page":"R295","DOI":"10.1152\/ajpregu.2000.279.1.R295","article-title":"Increased expression of spinal cord Fos protein induced by bladder stimulation after spinal cord injury","volume":"279","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.94","doi-asserted-by":"crossref","first-page":"R1027","DOI":"10.1152\/ajpregu.2000.278.4.R1027","article-title":"Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis","volume":"278","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.95","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.78"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.96","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1585-6_29"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.97","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0022-3565(25)10579-X","article-title":"Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats","volume":"274","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.98","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000286983.33184.9c"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.99","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.04.017"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.100","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5316-13.2014"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.101","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1523\/JNEUROSCI.19-11-04644.1999","article-title":"Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation","volume":"19","year":"1999","journal-title":"J Neurosci"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.102","first-page":"S3","article-title":"Neurophysiology of lower urinary tract function and dysfunction","volume":"5","year":"2003","journal-title":"Rev Urol"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.103","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021471"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.104","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01639-9"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.105","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1523\/JNEUROSCI.23-10-04355.2003","article-title":"Histological and electrical properties of rat dorsal root ganglion neurons innervating the lower urinary tract","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.106","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12308"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.107","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200810154"},{"key":"2023041302115948000_4.3.ENEURO.0381-16.2017.108","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.094375"}],"container-title":["eneuro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0381-16.2017","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0381-16.2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T12:30:24Z","timestamp":1750249824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eneuro.org\/lookup\/doi\/10.1523\/ENEURO.0381-16.2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":108,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,5,24]]},"published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1523\/ENEURO.0381-16.2017"],"URL":"https:\/\/doi.org\/10.1523\/eneuro.0381-16.2017","relation":{},"ISSN":["2373-2822"],"issn-type":[{"value":"2373-2822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}