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Substantial evidence supports the encoding of target direction in gaze- and body-centered coordinates within parietal and premotor regions. However, how the brain encodes the equally critical parameter of target distance remains less understood. Here, using Bayesian pattern component modeling of fMRI data during a delayed reach-to-target task, we dissociated the neural encoding of both target direction and the relative distances between target, gaze, and hand at early and late stages of motor planning. This approach revealed independent representations of direction and distance along the human dorsomedial reach pathway. During early planning, most premotor and superior parietal areas encoded a target\u2019s distance in single or multiple reference frames and encoded its direction. In contrast, distance encoding was magnified in gaze- and body-centric reference frames during late planning. These results emphasize a flexible and efficient human central nervous system that achieves goals by remapping sensory information related to multiple parameters, such as distance and direction, in the same brain areas.<\/jats:p>","DOI":"10.1523\/eneuro.0405-24.2024","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T13:55:18Z","timestamp":1731938118000},"page":"ENEURO.0405-24.2024","source":"Crossref","is-referenced-by-count":6,"title":["Neural Encoding of Direction and Distance across Reference Frames in Visually Guided Reaching"],"prefix":"10.1523","volume":"11","author":[{"given":"Alejandra Harris","family":"Caceres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1619-1513","authenticated-orcid":false,"given":"Deborah A.","family":"Barany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil 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