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We developed and applied analytical tools to investigate the effects of two EIB modulators, MK801 (NMDAR antagonist) and diazepam (GABAAR modulator), on periodic and aperiodic EEG features in freely-moving male Sprague Dawley rats. We investigated how, across three brain regions, EEG features are correlated with EIB modulation. We found that the periodic component was composed of seven frequency bands that presented region-dependent and compound-dependent changes. The aperiodic component was also different between compounds and brain regions. Importantly, the parametrization into periodic and aperiodic components unveiled correlations between quantitative EEG and plasma concentrations of pharmacological compounds. MK-801 exposures were positively correlated with the slope of the aperiodic component. Concerning the periodic component, MK-801 exposures correlated negatively with the peak frequency of low-\u03b3 oscillations but positively with those of high-\u03b3 and high-frequency oscillations (HFOs). As for the power, \u03b8 and low-\u03b3 oscillations correlated negatively with MK-801, whereas mid-\u03b3 correlated positively. Diazepam correlated negatively with the knee of the aperiodic component, positively to \u03b2 and negatively to low-\u03b3 oscillatory power, and positively to the modal frequency of \u03b8, low-\u03b3, mid-\u03b3, and high-\u03b3. In conclusion, correlations between exposures and pharmacodynamic effects can be better-understood thanks to the parametrization of EEG into periodic and aperiodic components. Such parametrization could be key in functional biomarker discovery.<\/jats:p>","DOI":"10.1523\/eneuro.0406-22.2023","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T17:45:18Z","timestamp":1679075118000},"page":"ENEURO.0406-22.2023","source":"Crossref","is-referenced-by-count":18,"title":["Glutamatergic and GABAergic Receptor Modulation Present Unique Electrophysiological Fingerprints in a Concentration-Dependent and Region-Specific Manner"],"prefix":"10.1523","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-5907","authenticated-orcid":false,"given":"Irene","family":"Gonzalez-Burgos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bainier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schoenenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-5270","authenticated-orcid":false,"given":"Miguel","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3477-689X","authenticated-orcid":false,"given":"Roger L.","family":"Redondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"2023042010550578000_10.4.ENEURO.0406-22.2023.1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF02190249","article-title":"Auditory evoked potentials in schizophrenic patients before and during neuroleptic treatment","volume":"242","year":"1993","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2023042010550578000_10.4.ENEURO.0406-22.2023.2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41398-022-02218-z","article-title":"From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans","volume":"12","year":"2022","journal-title":"Transl Psychiatry"},{"key":"2023042010550578000_10.4.ENEURO.0406-22.2023.3","doi-asserted-by":"crossref","unstructured":"Bak P (1996) How nature works: the science of self-organized criticality. 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