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While Ets-domain transcription factors (\n                    <jats:italic>Etv1<\/jats:italic>\n                    ,\n                    <jats:italic>Etv4<\/jats:italic>\n                    ,\n                    <jats:italic>Etv5<\/jats:italic>\n                    ) are downstream effectors of this pathway, only\n                    <jats:italic>Etv1<\/jats:italic>\n                    has been specifically linked to Schwann cell development. Here, we examined the functions of\n                    <jats:italic>Etv5<\/jats:italic>\n                    , which is expressed in Schwann cell precursors, neural crest cells and satellite glia, at embryonic stages and at low levels in mature Schwann cells. In hypomorphic\n                    <jats:italic>\n                      Etv5\n                      <jats:sup>tm1Kmm<\/jats:sup>\n                    <\/jats:italic>\n                    homozygous mutant mice, no overt defects in Schwann cell differentiation were observed at embryonic stages. To study the function of\n                    <jats:italic>Etv5<\/jats:italic>\n                    in juvenile (postnatal days 21\u201330) and mature adult (6\u2005month) mice, we generated\n                    <jats:italic>Etv5<\/jats:italic>\n                    conditional knock-outs (cKOs) using a\n                    <jats:italic>Sox10-Cre<\/jats:italic>\n                    driver. In juvenile male\n                    <jats:italic>Etv5<\/jats:italic>\n                    -cKO mice, Schwann cell numbers increased normally after a peripheral nerve crush injury, a response that was attenuated by 6\u2005months. Transmission electron microscopy of the naive sciatic nerve revealed a decline in axonal diameter and perturbed myelination in\n                    <jats:italic>Etv5<\/jats:italic>\n                    -cKO male and female mice. The innervated gastrocnemius muscle declined in area and volume in\n                    <jats:italic>Etv5<\/jats:italic>\n                    -cKO mice of both sexes, suggesting nerve structural abnormalities cause muscle atrophy. However, control and\n                    <jats:italic>Etv5<\/jats:italic>\n                    -cKO male and female mice performed similarly in motor behavior tests after a crush injury. Thus,\n                    <jats:italic>Etv5<\/jats:italic>\n                    is not essential for Schwann cell differentiation, but\n                    <jats:italic>Etv5<\/jats:italic>\n                    plays a crucial role in the age-dependent regulation of Schwann cell function, including nerve repair and the maintenance of axonal integrity in mature peripheral nerves.\n                  <\/jats:p>","DOI":"10.1523\/eneuro.0410-20.2025","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T17:50:14Z","timestamp":1753293014000},"page":"ENEURO.0410-20.2025","source":"Crossref","is-referenced-by-count":0,"title":["<i>Etv5<\/i>\n                    Is Required for Peripheral Nerve Function and the Injury Response"],"prefix":"10.1523","volume":"12","author":[{"given":"Lauren","family":"Belfiore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Balakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohannes","family":"Soenjaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Ghazale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Moffat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Zinyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-7762","authenticated-orcid":false,"given":"Lakshmy","family":"Vasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yacine","family":"Touahri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Amemiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tak-Ho","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan G.","family":"Stykel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Seth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Okawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E. 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