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Accordingly, the present work examined the effects of intermittent low-dose ketamine in male and female rats on behavioral sensitization to the locomotor-activating effects of ketamine, as well as associated molecular profiles in dopamine D1- and D2-receptor-expressing medium spiny neurons (D1- and D2-MSNs) of the nucleus accumbens (NAc). Following intra-NAc infusion of a Cre-inducible RiboTag virus, locomotor activity was measured in adult Drd1a-iCre and Drd2-iCre male and female rats in either diestrus or proestrus following repeated administration of ketamine (0, 10, or 20\u2005mg\/kg, i.p.) to evaluate the development of locomotor sensitization. Female\u2014but not male\u2014rats developed sensitization to the locomotor-activating effects of ketamine, occurring more rapidly in proestrus than in diestrus females at the lower dose tested. To examine enduring context- and cell-type-specific changes in translating mRNAs associated with sensitization to ketamine, RNA sequencing was performed on polyribosome-bound mRNA of D1- and D2-MSNs isolated from the NAc of sensitized females in a drug-free state. A greater number of differentially expressed genes were observed selectively in D1-MSNs of ketamine-treated proestrus versus diestrus females, which were broadly related to regulation of transcription and epitranscriptional modification. These findings provide novel evidence of cell-type-specific and estrous cycle-dependent molecular profiles responsive to intermittent ketamine treatment in female rats and identify posttranscriptional mechanisms with relevance to ketamine's effects on behavioral plasticity.<\/jats:p>","DOI":"10.1523\/eneuro.0419-25.2025","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:50:16Z","timestamp":1765997416000},"page":"ENEURO.0419-25.2025","update-policy":"https:\/\/doi.org\/10.1523\/eneuro.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Estrous Cycle Influences Cell-Type-Specific Translatomic Signatures of Repeated Ketamine Exposure in the Rat Nucleus Accumbens"],"prefix":"10.1523","volume":"13","author":[{"given":"Samantha K.","family":"Saland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-5807","authenticated-orcid":false,"given":"Florian","family":"Duclot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-2079","authenticated-orcid":false,"given":"Mary K.","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7095-725X","authenticated-orcid":false,"given":"Mohamed","family":"Kabbaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"2026012110501291000_13.1.ENEURO.0419-25.2025.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.038"},{"key":"2026012110501291000_13.1.ENEURO.0419-25.2025.2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.49"},{"key":"2026012110501291000_13.1.ENEURO.0419-25.2025.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.01.069"},{"key":"2026012110501291000_13.1.ENEURO.0419-25.2025.4","unstructured":"Andrews S , Krueger F , Seconds-Pichon A , Biggins F , Wingett S (2015) Babraham bioinformatics. 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