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Here, we show that neuregulin-1, a glial growth factor, induces inflammatory cytokines and promotes phagocytic activity\n                    <jats:italic>in vitro<\/jats:italic>\n                    and augments microglial activation and plaque formation in 5XFAD Alzheimer\u2019s mice. Brain-specific targeting of neuregulin-1 by intraventricular delivery of a novel neuregulin-1 fusion protein antagonist, GlyB4, significantly alters microglial morphology and function to a nonpathogenic morphology in early-stage 5XFAD mice and prevents plaques from forming. Once plaques have already formed, GlyB4 reduces new plaque formation and prevents synaptic loss. Selective, targeted disruption of neuregulin-1 signaling on brain microglia with GlyB4 could be a novel \u201cupstream\u201d approach to slow or stop disease progression in Alzheimer\u2019s disease.\n                  <\/jats:p>","DOI":"10.1523\/eneuro.0422-23.2023","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T13:50:41Z","timestamp":1698673841000},"page":"ENEURO.0422-23.2023","source":"Crossref","is-referenced-by-count":6,"title":["Prevention of Alzheimer Pathology by Blocking Neuregulin Signaling on Microglia"],"prefix":"10.1523","volume":"10","author":[{"given":"Jianguo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph 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