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Adolescence is a particularly sensitive period for the development of social behaviors, yet how social experience during this window shapes prosocial behavior remains poorly understood. Here, we used behavioral assays to examine how social isolation at different ages affects emotional discrimination and affiliative helping behavior in mice of both sexes. We found that adult mice raised in social isolation since weaning failed to allogroom distressed conspecifics and were unable to distinguish stressed from unstressed mice in an emotional discrimination assay. Remarkably, 2 weeks of post-weaning social isolation was already sufficient to impair both emotional discrimination and prosocial allogrooming, and these deficits persisted despite 2 months of resocialization. In contrast, 2 weeks of adult social isolation spared emotional discrimination but impaired allogrooming toward stressed conspecifics. These findings reveal a dissociation between emotional discrimination and prosocial helping behavior. Overall, this work identifies adolescence as a sensitive period for the development of emotional state recognition and provides a behavioral framework for investigating how early social experience sculpts neural circuits underlying empathy and stress buffering.<\/jats:p>","DOI":"10.1523\/eneuro.0441-25.2026","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:50:19Z","timestamp":1782755419000},"page":"ENEURO.0441-25.2026","update-policy":"https:\/\/doi.org\/10.1523\/eneuro.crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Adolescent Social Isolation Induces Persistent Impairments in Emotional Discrimination and Helping Behavior"],"prefix":"10.1523","volume":"13","author":[{"given":"Hyo Gun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9020-0003","authenticated-orcid":false,"given":"Yi","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105319"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.09.002"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010213-115202"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.018"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4785"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.05.013"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010814-015240"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.8","doi-asserted-by":"crossref","first-page":"105820","DOI":"10.1016\/j.neubiorev.2024.105820","article-title":"Revisiting adolescence as a sensitive period for sociocultural processing","volume":"164","author":"Cheng","year":"2024","journal-title":"Neurosci Biobehav Rev"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2012.08.009"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.10","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2015.0077"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.11","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.72"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3472(76)80051-6"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.13","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420100205"},{"key":"2026071010501055000_13.7.ENEURO.0441-25.2026.14","doi-asserted-by":"crossref","unstructured":"Eisenberg N , Fabes RA , Spinrad TL (2007) Prosocial development. 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