{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:54:57Z","timestamp":1787900097470,"version":"build-2784847793"},"reference-count":170,"publisher":"Society for Neuroscience","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"HHS | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"crossref","award":["R01 AA027754"],"award-info":[{"award-number":["R01 AA027754"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000027","name":"HHS | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"crossref","award":["F30 AA029261"],"award-info":[{"award-number":["F30 AA029261"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"crossref"}]},{"name":"HHS | NIH | National Institute on Aging","award":["R01 AG072900"],"award-info":[{"award-number":["R01 AG072900"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["eNeuro"],"accepted":{"date-parts":[[2025,2,26]]},"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>Delayed motor development is an early clinical sign of fetal alcohol spectrum disorders. However, changes at the neural circuit level that underlie early motor differences are underexplored. The striatum, the principal input nucleus of the basal ganglia, plays an important role in motor learning in adult animals, and the maturation of the striatal circuit has been associated with the development of early motor behaviors. Here, we briefly exposed pregnant C57BL\/6 dams to ethanol (5% w\/w) in a liquid diet on embryonic days 13.5\u201316.5 and assessed the mouse progeny using a series of nine brief motor behavior tasks on postnatal days 2\u201314. Live brain slices were then obtained from behaviorally tested mice for whole-cell voltage- and current-clamp electrophysiology to assess GABAergic\/glutamatergic synaptic activity and passive\/active properties in two populations of striatal neurons: GABAergic interneurons and spiny striatal projection neurons. Electrophysiologically recorded spiny striatal projection neurons were also filled intracellularly with biocytin for post hoc analysis of dendritic morphology. We found that prenatal ethanol exposure resulted in developmental motor delays that were more severe in male mice and coincided with sex-dependent differences in the maturation of striatal neurons. Our findings indicate that prenatal ethanol exposure results in dynamic morphological and functional changes to the developmental trajectories of striatal neurons commensurate with the development of motor behaviors that differ between male and female mice.<\/jats:p>","DOI":"10.1523\/eneuro.0448-24.2025","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T19:06:01Z","timestamp":1741979161000},"page":"ENEURO.0448-24.2025","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal Ethanol Exposure Results in Cell Type, Age, and Sex-Dependent Differences in the Neonatal Striatum That Coincide with Early Motor Deficits"],"prefix":"10.1523","volume":"12","author":[{"given":"Adelaide R.","family":"Tousley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Deykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Koc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela W. L.","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermes H.","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(02)00046-3"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-3472(75)90114-1"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.3","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901390202"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.4","first-page":"1229","article-title":"Functional comparison of corticostriatal and thalamostriatal postsynaptic responses in striatal neurons of the mouse","volume":"223","author":"Arias-Garc\u00eda","year":"2018","journal-title":"Brain Struct Funct"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.5","doi-asserted-by":"crossref","first-page":"e12630","DOI":"10.1111\/gbb.12630","article-title":"Assessing the developmental trajectory of mouse models of neurodevelopmental disorders: social and communication deficits in mice with neurexin 1a deletion","volume":"19","author":"Armstrong","year":"2019","journal-title":"Genes Brain Behav"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.6","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2358"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.7","first-page":"e132","article-title":"Profile of the first 1,400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorder at the Washington state fetal alcohol syndrome diagnostic & prevention network","volume":"17","author":"Astley","year":"2010","journal-title":"Can J Clin Pharmacol"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4352-11.2012"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2044"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2013.05.001"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.11","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.5.2204"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.12","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412438697"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72588-1"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109511"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.15","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.3389\/fncir.2020.00045","article-title":"Auditory long-range parvalbumin cortico-striatal neurons","volume":"14","author":"Bertero","year":"2020","journal-title":"Front Neural Circuits"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.16","doi-asserted-by":"publisher","DOI":"10.2307\/3432648"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.17","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1530-0277.1993.tb05651.x","article-title":"Prenatal ethanol exposure alters ethanol-induced dopamine release in nucleus accumbens and striatum in male and female rats","volume":"17","author":"Blanchard","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.18","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.241"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.19","doi-asserted-by":"publisher","DOI":"10.1002\/CNE.24665"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0892-0362(95)02027-6","article-title":"Effects of prenatal ethanol exposure on dopamine systems in C57BL\/6J mice","volume":"18","author":"Boggan","year":"1996","journal-title":"Neurotoxicol Teratol"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00774-6"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.034"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.23","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agr166"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2007.00469.x"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.25","doi-asserted-by":"crossref","first-page":"3181\u20133196","DOI":"10.1210\/en.2016-1160","article-title":"Neonatal masculinization blocks increased excitatory synaptic input in female rat nucleus accumbens core","volume":"157","author":"Cao","year":"2016","journal-title":"Endocrinology"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.26","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1111\/febs.15908","article-title":"Interpreting the role of the striatum during multiple phases of motor learning","volume":"289","author":"Cataldi","year":"2021","journal-title":"FEBS J"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.041"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2017.01.005"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.29","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13806"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.30","doi-asserted-by":"crossref","unstructured":"Chesselet M-F , Plotkin JL , Wu N , Levine MS (2007) Development of striatal fast-spiking GABAergic interneurons. In: Progress in brain research, GABA and the basal ganglia ( Tepper JM , Abercrombie ED , Bolam JP , eds), pp 261\u2013272. Los Angeles, CA : Elsevier.","DOI":"10.1016\/S0079-6123(06)60015-0"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.31","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/814567"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2005.07.016"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2006.08.002"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.31887\/DCNS.2012.14.3\/jcrawley","article-title":"Translational animal models of autism and neurodevelopmental disorders","volume":"14","author":"Crawley","year":"2012","journal-title":"Dialogues Clin Neurosci"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.35","doi-asserted-by":"publisher","DOI":"10.1038\/nature11846"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16385-4"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.37","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(98)00028-0"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.38","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90526-6"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.39","doi-asserted-by":"publisher","DOI":"10.1186\/1866-1955-4-18"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1527-09.2009"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.41","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2011.00024"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.42","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy094"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.43","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1093\/cercor\/bhz199","article-title":"Prenatal exposure to ethanol alters synaptic activity in layer V\/VI pyramidal neurons of the somatosensory cortex","volume":"30","author":"Delatour","year":"2019","journal-title":"Cereb Cortex"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neuroscience.2015.07.068","article-title":"The gestational foundation of sex differences in development and vulnerability","volume":"342","author":"DiPietro","year":"2017","journal-title":"Neuroscience"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.45","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12930"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.46","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ridd.2016.05.009","article-title":"Visual-motor integration, visual perception, and fine motor coordination in a population of children with high levels of fetal alcohol spectrum disorder","volume":"55","author":"Doney","year":"2016","journal-title":"Res Dev Disabil"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.47","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/DBP.0000000000000107","article-title":"Fine motor skills in children with prenatal alcohol exposure or fetal alcohol spectrum disorder","volume":"35","author":"Doney","year":"2014","journal-title":"J Dev Behav Pediatr"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.48","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00687.2014"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.49","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1111\/ejn.14670","article-title":"Activation of parvalbumin-expressing neurons reconfigures neuronal ensembles in murine striatal microcircuits","volume":"53","author":"Duhne","year":"2020","journal-title":"Eur J Neurosci"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3721-13.2013"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.51","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2703"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.52","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0091-3057(81)90103-9","article-title":"Viability and sensorimotor development of mice exposed to prenatal short-term ethanol","volume":"14","author":"Fish","year":"1981","journal-title":"Pharmacol Biochem Behav"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.53","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/acer.15017","article-title":"Sex-related differences among individuals assessed for fetal alcohol spectrum disorder in Canada","volume":"47","author":"Flannigan","year":"2023","journal-title":"Alcohol Clin Exp Res"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.54","doi-asserted-by":"publisher","DOI":"10.1016\/0003-3472(65)90041-2"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.55","first-page":"54","article-title":"Fetal alcohol syndrome among children aged 7\u20139 years\u2014Arizona, Colorado, and New York, 2010","volume":"64","author":"Fox","year":"2015","journal-title":"Morb Mortal Wkly Rep"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.56","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/ejn.14581","article-title":"Ablation of striatal somatostatin interneurons affects MSN morphology and electrophysiological properties, and increases cocaine-induced hyperlocomotion in mice","volume":"51","author":"Gazan","year":"2019","journal-title":"Eur J Neurosci"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.57","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2660-08.2008"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.03.010"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.59","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4870-09.2010"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00215293","article-title":"Multifaceted alterations of the thalamo-cortico-thalamic loop in adult rats prenatally exposed to ethanol","volume":"191","author":"Granato","year":"1995","journal-title":"Anat Embryol"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.61","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021691"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.62","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0341-3"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.63","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.dcn.2018.02.008","article-title":"Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure","volume":"30","author":"Hendrickson","year":"2018","journal-title":"Dev Cogn Neurosci"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.06.081"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.65","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.3389\/fncel.2013.00048","article-title":"Physiological temperature during brain slicing enhances the quality of acute slice preparations","volume":"7","author":"Huang","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.66","first-page":"419","article-title":"Effects of ethanol exposure on brain sodium channels","volume":"6","author":"Hunt","year":"1985","journal-title":"Alcohol Drug Res"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.67","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3632"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.095"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.69","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab438"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.70","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25944"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.71","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fgene.2014.00161","article-title":"Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders","volume":"5","author":"Kleiber","year":"2014","journal-title":"Front Genet"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.72","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35657"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.73","doi-asserted-by":"crossref","first-page":"111531","DOI":"10.1016\/j.celrep.2022.111531","article-title":"Cholinergic control of striatal GABAergic microcircuits","volume":"41","author":"Kocaturk","year":"2022","journal-title":"Cell Rep"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.74","doi-asserted-by":"publisher","DOI":"10.1038\/nature11052"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.75","doi-asserted-by":"publisher","DOI":"10.1113\/JP278416"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.76","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3100"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.77","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-020-00320-9"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.01.028"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.79","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.1919"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.80","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1161-12.2012"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.033"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.82","doi-asserted-by":"crossref","first-page":"ENEURO.0359-21.2021","DOI":"10.1523\/ENEURO.0359-21.2021","article-title":"L-type calcium channels contribute to ethanol-induced aberrant tangential migration of primordial cortical GABAergic interneurons in the embryonic medial prefrontal cortex","volume":"9","author":"Lee","year":"2022","journal-title":"eNeuro"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.83","doi-asserted-by":"crossref","first-page":"105074","DOI":"10.1016\/j.nbd.2020.105074","article-title":"In utero alcohol exposure exacerbates endothelial protease activity from pial microvessels and impairs GABA interneuron positioning","volume":"145","author":"L\u00e9ger","year":"2020","journal-title":"Neurobiol Dis"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.84","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1268-12.2013"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.85","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890180108"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.013"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.06.044"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.88","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2014.00022"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.89","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2217\/epi-2017-0147","article-title":"Time- and sex-dependent associations between prenatal alcohol exposure and placental global DNA methylation","volume":"10","author":"Loke","year":"2018","journal-title":"Epigenomics"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.90","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24004"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.91","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90008-X"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.92","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.brainres.2017.10.005","article-title":"Developmental ethanol exposure alters the morphology of mouse prefrontal neurons in a layer-specific manner","volume":"1678","author":"Louth","year":"2018","journal-title":"Brain Res"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.93","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90804-T"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.94","doi-asserted-by":"publisher","DOI":"10.1126\/science.2467382"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.95","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/jpc.13240","article-title":"Gross motor performance in children prenatally exposed to alcohol and living in remote Australia","volume":"52","author":"Lucas","year":"2016","journal-title":"J Paediatr Child Health"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.96","doi-asserted-by":"crossref","first-page":"134700","DOI":"10.1016\/j.neulet.2019.134700","article-title":"Moderate prenatal alcohol exposure reduces parvalbumin expressing GABAergic interneurons in the dorsal hippocampus of adult male and female rat offspring","volume":"718","author":"Madden","year":"2020","journal-title":"Neurosci Lett"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.97","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s40478-020-01089-z","article-title":"Prenatal alcohol exposure is a leading cause of interneuronopathy in humans","volume":"8","author":"Marguet","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.98","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-16-06063.2000"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.99","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107832"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.100","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.031"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.101","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2011.12.002"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.102","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9167-9"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.103","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3319"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.104","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.04.010"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.105","first-page":"374","article-title":"Epidemiology of fetal alcohol syndrome among American Indians of the southwest","volume":"30","author":"May","year":"1983","journal-title":"Soc Biol"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1988.tb00188.x"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.107","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.04.024"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.108","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105856"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.109","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(83)90059-8"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brainres.2017.07.028","article-title":"Effect of prenatal exposure to ethanol on the pyramidal tract in developing rats","volume":"1672","author":"Miller","year":"2017","journal-title":"Brain Res"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.111","first-page":"108","article-title":"Depolarizing IPSPs and depolarization by GABA of rat neostriatum cells in vitro","volume":"45","author":"Misgeld","year":"1982","journal-title":"Exp Brain Res"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.112","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41593-020-0592-z","article-title":"Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders","volume":"23","author":"Mohammad","year":"2020","journal-title":"Nat Neurosci"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.113","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(87)90088-2"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.114","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-15-05723.1998"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.115","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.expneurol.2010.02.003","article-title":"Prenatal exposure to ethanol affects postnatal neurogenesis in thalamus","volume":"223","author":"Mooney","year":"2010","journal-title":"Exp Neurol"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.116","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.08.014"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.117","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3389\/fnhum.2021.695855","article-title":"Neurodevelopmental trajectories following prenatal alcohol exposure","volume":"15","author":"Moore","year":"2022","journal-title":"Front Hum Neurosci"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.118","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.083"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.119","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2012.00879.x"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.120","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-03-00654.2002"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.121","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20705"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.122","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.12.032"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.123","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00532-0"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.124","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.005"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.125","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.353"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.126","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4260"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.127","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12261"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.128","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04303.x"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.129","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(02)00649-6"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.130","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.alcohol.2011.11.008","article-title":"Effects of exposure to moderate levels of ethanol during prenatal brain development on dendritic length, branching, and spine density in the nucleus accumbens and dorsal striatum of adult rats","volume":"46","author":"Rice","year":"2012","journal-title":"Alcohol"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.131","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.07.018"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.132","doi-asserted-by":"crossref","first-page":"108310","DOI":"10.1016\/j.neuropharm.2020.108310","article-title":"Prenatal alcohol exposure reduces posterior dorsomedial striatum excitability and motivation in a sex- and age-dependent fashion","volume":"180","author":"Roselli","year":"2020","journal-title":"Neuropharmacology"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.133","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1038\/s41386-022-01327-z","article-title":"Moderate prenatal alcohol exposure modifies sex-specific CRFR1 activity in the central amygdala and anxiety-like behavior in adolescent offspring","volume":"47","author":"Rouzer","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.134","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0778-9"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.135","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3924"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.136","doi-asserted-by":"crossref","first-page":"102439","DOI":"10.1016\/j.isci.2021.102439","article-title":"Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex","volume":"24","author":"Salem","year":"2021","journal-title":"iScience"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.137","doi-asserted-by":"crossref","first-page":"1011974","DOI":"10.3389\/fcell.2022.1011974","article-title":"Cell type-specific changes in Wnt signaling and neuronal differentiation in the developing mouse cortex after prenatal alcohol exposure during neurogenesis","volume":"10","author":"Sambo","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.138","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2015.07.003"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.139","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2016.06.003"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.140","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.141","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07630.x"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.142","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.3389\/fncel.2010.00011","article-title":"GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems","volume":"4","author":"Sernagor","year":"2010","journal-title":"Front Cell Neurosci"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.143","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1462-15.2015"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.144","doi-asserted-by":"crossref","first-page":"e48648","DOI":"10.7554\/eLife.48648","article-title":"The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero","volume":"8","author":"Skorput","year":"2019","journal-title":"Elife"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.145","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.07.004"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.146","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs342"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.147","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.007"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.148","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-015-0042-z"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.149","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-018-0961-4"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.150","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/WNR.0000000000001234","article-title":"Localization of chloride co-transporters in striatal neurons","volume":"30","author":"Tapia","year":"2019","journal-title":"Neuroreport"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.151","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-010-0446-7"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.152","doi-asserted-by":"publisher","DOI":"10.1159\/000017308"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.153","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.10.008"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.154","first-page":"e395","article-title":"Incidence and prevalence of fetal alcohol spectrum disorder by sex and age group in Alberta, Canada","volume":"21","author":"Thanh","year":"2014","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.155","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.alcohol.2022.08.003","article-title":"Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol","volume":"107","author":"Tousley","year":"2022","journal-title":"Alcohol"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.156","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22520"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.157","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3390\/children9060801","article-title":"Intra-individual variability in gross motor development in healthy full-term infants aged 0\u201313 months and associated factors during child rearing","volume":"9","author":"Tupsila","year":"2022","journal-title":"Children"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.158","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/ped.13963","article-title":"Motor trajectories of preterm and full-term infants in the first year of life","volume":"61","author":"Valentini","year":"2019","journal-title":"Pediatr Int"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.159","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4317-14.2015"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.160","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-14-60"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.161","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.05.014"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.162","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(99)00050-9"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.163","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5599-07.2008"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.164","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-07-02397.1996"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.165","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30150-4"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.166","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.074"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.167","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21529"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.168","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1111\/febs.15872","article-title":"Interneuron development and dysfunction","volume":"289","author":"Yang","year":"2021","journal-title":"FEBS J"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.169","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00915-1"},{"key":"2025032710501671000_12.3.ENEURO.0448-24.2025.170","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042443"}],"container-title":["eneuro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0448-24.2025","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0448-24.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T18:02:20Z","timestamp":1743098540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eneuro.org\/lookup\/doi\/10.1523\/ENEURO.0448-24.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":170,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3,27]]},"published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1523\/ENEURO.0448-24.2025"],"URL":"https:\/\/doi.org\/10.1523\/eneuro.0448-24.2025","relation":{},"ISSN":["2373-2822"],"issn-type":[{"value":"2373-2822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}