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Rac1 has been implicated in active forgetting, but whether it also constrains the consolidation of new memories remains unclear. Here we show that systemic administration of the Rac1 inhibitor 1A-116 after training in the novel object recognition task markedly extends memory persistence in rats. A single post-training injection of 1A-116 enhanced recognition memory for at least 28\u2005d without altering locomotor- or anxiety-related behaviors. When given after a brief, subthreshold training session that normally supports only short-term memory, 1A-116 enabled long-term retention that required hippocampal protein synthesis. This promnesic effect was time-dependent, independent of sex, and consistent with Rac1 acting as a negative regulator of memory consolidation rather than merely promoting forgetting. These findings indicate that Rac1 activity after learning limits the consolidation process itself, functioning as a molecular brake on recognition memory stabilization, and suggest that its inhibition may represent a therapeutic avenue to enhance cognitive durability in both healthy and pathological conditions.<\/jats:p>","DOI":"10.1523\/eneuro.0448-25.2026","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:50:24Z","timestamp":1774374624000},"page":"ENEURO.0448-25.2026","update-policy":"https:\/\/doi.org\/10.1523\/eneuro.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Rac1 Constrains Memory Consolidation"],"prefix":"10.1523","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4752-3879","authenticated-orcid":false,"given":"Gabriel 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