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Animal models of syndromic forms of ASD, such as neurofibromatosis type 1, may be of use in screening for such treatments.<jats:italic>Drosophila<\/jats:italic>larvae lacking<jats:italic>Nf1<\/jats:italic>expression exhibit tactile hypersensitivity following mechanical stimulation, proposed to mirror the sensory sensitivity issues comprising part of the ASD diagnostic criteria. Such behavior is associated with synaptic dysfunction at the neuromuscular junction (NMJ). Both phenotypes may thus provide tractable outputs with which to screen for potential ASD therapies. In this study, we demonstrate that, while loss of<jats:italic>Nf1<\/jats:italic>expression within the embryo is sufficient to impair NMJ synaptic transmission in the larva, constitutive<jats:italic>Nf1<\/jats:italic>knock-down is required to induce tactile hypersensitivity, suggesting that a compound must be administered throughout development to rescue this behavior. With such a feeding regime, we identify two compounds from a targeted, low-throughput screen that significantly and consistently reduce, but do not fully rescue, tactile hypersensitivity in<jats:italic>Nf1<jats:sup>P1<\/jats:sup><\/jats:italic>larvae. These are the HMG CoA-reductase inhibitor simvastatin, and the BK<jats:sub>Ca<\/jats:sub>channel activator BMS-204352. At the NMJ, both compounds induce a significant reduction in the enhanced spontaneous transmission frequency of<jats:italic>Nf1<jats:sup>P1<\/jats:sup><\/jats:italic>larvae, though again not to the level of vehicle-treated controls. However, both compounds fully rescue the increased quantal size of<jats:italic>Nf1<jats:sup>P1<\/jats:sup><\/jats:italic>mutants, with simvastatin also fully rescuing their reduced quantal content. Thus, the further study of both compounds as potential ASD interventions is warranted.<\/jats:p>","DOI":"10.1523\/eneuro.0461-22.2023","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T17:51:01Z","timestamp":1682531461000},"page":"ENEURO.0461-22.2023","source":"Crossref","is-referenced-by-count":7,"title":["A Targeted, Low-Throughput Compound Screen in a<i>Drosophila<\/i>Model of Neurofibromatosis Type 1 Identifies Simvastatin and BMS-204352 as Potential Therapies for Autism Spectrum Disorder (ASD)"],"prefix":"10.1523","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8498-1691","authenticated-orcid":false,"given":"Alex","family":"Dyson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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