{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T22:30:12Z","timestamp":1716330612862},"reference-count":42,"publisher":"Society for Neuroscience","issue":"5","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":191,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["110027\/Z\/15\/Z\/280116"],"award-info":[{"award-number":["110027\/Z\/15\/Z\/280116"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["eNeuro"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oligodendrogenesis is the process by which new oligodendrocytes are produced in the CNS. Oligodendrocytes form myelin, which has a vital role in neural signal transmission and integration. Here we tested mice with reduced adult oligodendrogenesis in the Morris water maze, a test of spatial learning. These mice were found to have impaired long-term (28 d) spatial memory. However, when 7,8-dihydroxyflavone (7,8-DHF) was administered immediately after each training session, their long-term spatial memory impairment was rescued. An increase in the number of newly formed oligodendrocytes in the corpus callosum was also observed. 7,8-DHF has previously been shown to improve spatial memory in animal models of Alzheimer\u2019s disease, post-traumatic stress disorder, Wolfram syndrome and Down syndrome, as well as in normal aging. Understanding the underlying mechanisms of the effect of this drug on spatial memory is therefore helpful in assessing it for clinical relevance and development.<\/jats:p>","DOI":"10.1523\/eneuro.0498-22.2023","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T17:50:16Z","timestamp":1682358616000},"page":"ENEURO.0498-22.2023","source":"Crossref","is-referenced-by-count":2,"title":["Rescue of Long-Term Spatial Memory by 7,8-Dihydroxyflavone in Mice with Reduced Oligodendrogenesis"],"prefix":"10.1523","volume":"10","author":[{"given":"Florence","family":"Rawlings-Mortimer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Johansen-Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.1","doi-asserted-by":"crossref","first-page":"109939","DOI":"10.1016\/j.pnpbp.2020.109939","article-title":"Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period","volume":"101","year":"2020","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20906"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.02.045"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091453"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.5","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12543"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.6","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1997.0641"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.7","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00135"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02911.x"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00401-017-1741-7","article-title":"Myelin regulatory factor drives remyelination in multiple sclerosis","volume":"134","year":"2017","journal-title":"Acta Neuropathol"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.031"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.11","doi-asserted-by":"crossref","first-page":"965500","DOI":"10.3389\/fnins.2022.965500","article-title":"Sex-specific stress and biobehavioral responses to human experimenters in rats","volume":"16","year":"2022","journal-title":"Front Neurosci"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0487-18.2018"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.13","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.biopsych.2021.07.014","article-title":"Sex differences in the role of CNIH3 on spatial memory and synaptic plasticity","volume":"90","year":"2021","journal-title":"Biol Psychiatry"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.03.008"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.15","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13432"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3390\/antiox8060163","article-title":"Timing of treatment with the flavonoid 7,8-DHF critically impacts on its effects on learning and memory in the Ts65Dn mouse","volume":"8","year":"2019","journal-title":"Antioxidants"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.17","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/dneu.22729","article-title":"Blockade of TrkB but not P75NTR activates a subpopulation of quiescent neural precursor cells and enhances neurogenesis in the adult mouse hippocampus","volume":"79","year":"2019","journal-title":"Dev Neurobiol"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0747-14.2014"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913572107"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.19.8856"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.21","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0510-4"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41356"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.23","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254960"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.24","doi-asserted-by":"publisher","DOI":"10.1016\/0023-9690(81)90020-5"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.25","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00205"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0582-1"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.27","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3390\/ph14080704","article-title":"Do small molecules activate the TrkB receptor in the same manner as BDNF? Limitations of published TrkB low molecular agonists and screening for novel TrkB orthosteric agonists","volume":"14","year":"2021","journal-title":"Pharmaceuticals"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.28","doi-asserted-by":"crossref","first-page":"113592","DOI":"10.1016\/j.bbr.2021.113592","article-title":"Estradiol effects on spatial memory in women","volume":"417","year":"2022","journal-title":"Behav Brain Res"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/glia.22927","article-title":"Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination","volume":"64","year":"2016","journal-title":"Glia"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.30","doi-asserted-by":"crossref","first-page":"e0281264","DOI":"10.1371\/journal.pone.0281264","article-title":"DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact","volume":"18","year":"2023","journal-title":"PLoS One"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74279-3"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.32","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1038\/s41598-021-81768-6","article-title":"Liraglutide, 7,8-DHF and their co-treatment prevents loss of vision and cognitive decline in a Wolfram syndrome rat model","volume":"11","year":"2021","journal-title":"Sci Rep"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.33","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2935"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.08.018"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.10.013"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.36","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20969"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2014.07.003"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2014.10.002"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.39","doi-asserted-by":"publisher","DOI":"10.1159\/000323170"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2190-07.2007"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07830.x"},{"key":"2023050510550500000_10.5.ENEURO.0498-22.2023.42","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.243"}],"container-title":["eneuro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0498-22.2023","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/ENEURO.0498-22.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T17:55:28Z","timestamp":1683309328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eneuro.org\/lookup\/doi\/10.1523\/ENEURO.0498-22.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,24]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,5]]},"published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1523\/ENEURO.0498-22.2023"],"URL":"https:\/\/doi.org\/10.1523\/eneuro.0498-22.2023","relation":{},"ISSN":["2373-2822"],"issn-type":[{"value":"2373-2822","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,24]]}}}