{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:39:27Z","timestamp":1791236367680,"version":"4.1.0"},"reference-count":52,"publisher":"Society for Neuroscience","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2019R1I1A2A01041345"],"award-info":[{"award-number":["NRF-2019R1I1A2A01041345"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF-2022M3E5E8017420"],"award-info":[{"award-number":["NRF-2022M3E5E8017420"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["eNeuro"],"accepted":{"date-parts":[[2025,4,4]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Chronic pain affects millions globally, yet no universally effective treatment exists. The primary motor cortex (M1) has been a key target for chronic pain therapies, with electrical stimulation of the M1 (eMCS) showing promise. However, the mechanisms underlying M1-mediated analgesic effects are not fully understood. We investigated the role of the primary somatosensory cortex (S1) in M1-mediated analgesia using a neuropathic pain mouse model. In this model, neuropathic pain is associated with increased spontaneous activity of layer V pyramidal neurons (LV-PNs) in the S1, partly attributed to the reduced activity of somatostatin-expressing inhibitory neurons (SST<jats:sup>+<\/jats:sup>INs), which normally suppress LV-PNs. While manipulation of either LV-PNs or SST<jats:sup>+<\/jats:sup>INs has been shown to alleviate pain, the role of S1 in M1-mediated analgesia has not been identified. Using multichannel silicon probes, we applied eMCS to neuropathic mice and observed significant analgesia. Histological analyses revealed that eMCS activated SST<jats:sup>+<\/jats:sup>INs and suppressed hyperactivity of LV-PNs in the S1, suggesting that eMCS suppresses pain by modulating S1 neuronal circuits, alongside other pain-related regions. Notably, eMCS induced long-lasting analgesia, persisting for at least 2\u2005d poststimulation. These findings implicate S1 as a critical mediator of eMCS-induced analgesia and suggest eMCS as a potential durable therapeutic strategy for chronic pain.<\/jats:p>","DOI":"10.1523\/eneuro.0541-24.2025","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T17:50:16Z","timestamp":1744653016000},"page":"ENEURO.0541-24.2025","source":"Crossref","is-referenced-by-count":3,"title":["Electrical Stimulation of the M1 Activates Somatostatin Interneurons in the S1: Potential Mechanisms Underlying Pain Suppression"],"prefix":"10.1523","volume":"12","author":[{"given":"Junhee","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Geon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taehyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8906-901X","authenticated-orcid":false,"given":"Myungin","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"2025042910501595000_12.4.ENEURO.0541-24.2025.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.036"},{"key":"2025042910501595000_12.4.ENEURO.0541-24.2025.2","unstructured":"Allen Institute for Brain Science (2011) Allen reference Atlas \u2013 mouse brain [brain atlas]. 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